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Gcc2 GRIP and coiled-coil domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309798, updated on 9-Dec-2024

Summary

Official Symbol
Gcc2provided by RGD
Official Full Name
GRIP and coiled-coil domain containing 2provided by RGD
Primary source
RGD:1305732
See related
EnsemblRapid:ENSRNOG00000000823 AllianceGenome:RGD:1305732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; protein localization to organelle; and retrograde transport, endosome to Golgi. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be active in Golgi apparatus. Orthologous to human GCC2 (GRIP and coiled-coil domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 96.5), Brain (RPKM 88.0) and 9 other tissues See more
Orthologs
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Genomic context

See Gcc2 in Genome Data Viewer
Location:
20q11
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (26788472..26836728)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (26247394..26293613)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (27832960..27879764)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene dermatan sulfate epimerase Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 5 Neighboring gene uncharacterized LOC134483908 Neighboring gene U6 spliceosomal RNA Neighboring gene LIM zinc finger domain containing 1 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Golgi ribbon formation  
involved_in Golgi ribbon formation  
NOT involved_in Golgi to plasma membrane protein transport  
involved_in late endosome to Golgi transport  
involved_in late endosome to Golgi transport  
involved_in late endosome to Golgi transport  
involved_in microtubule anchoring  
involved_in microtubule anchoring  
involved_in microtubule organizing center organization  
involved_in microtubule organizing center organization  
involved_in protein localization to Golgi apparatus  
involved_in protein localization to Golgi apparatus  
involved_in protein targeting to lysosome  
involved_in protein targeting to lysosome  
involved_in recycling endosome to Golgi transport  
involved_in recycling endosome to Golgi transport  
involved_in regulation of protein exit from endoplasmic reticulum  
involved_in regulation of protein exit from endoplasmic reticulum  
involved_in retrograde transport, endosome to Golgi  
Component Evidence Code Pubs
is_active_in Golgi apparatus  
located_in Golgi apparatus  
located_in Golgi membrane  
located_in cytosol  
located_in membrane  
located_in nucleoplasm  
located_in trans-Golgi network  
located_in trans-Golgi network  

General protein information

Preferred Names
GRIP and coiled-coil domain-containing protein 2
Names
185 kDa Golgi coiled-coil protein
LIM and senescent cell antigen-like domains 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107633.2NP_001101103.1  GRIP and coiled-coil domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001101103.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    D3ZZL9
    Conserved Domains (5) summary
    COG1196
    Location:4621243
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:26830
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam01465
    Location:16091651
    GRIP; GRIP domain
    pfam07851
    Location:106203
    TMPIT; TMPIT-like protein
    pfam16704
    Location:15431607
    Rab_bind; Rab binding domain
  2. NM_001434628.1NP_001421557.1  GRIP and coiled-coil domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A0H2UH94

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    26788472..26836728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256375.5XP_006256437.1  GRIP and coiled-coil domain-containing protein 2 isoform X1

    Related
    ENSRNOP00000001092.4, ENSRNOT00000001092.6
    Conserved Domains (5) summary
    COG1196
    Location:4641245
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:28832
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam01465
    Location:16111653
    GRIP; GRIP domain
    pfam07851
    Location:108205
    TMPIT; TMPIT-like protein
    pfam16704
    Location:15451609
    Rab_bind; Rab binding domain
  2. XM_039098762.2XP_038954690.1  GRIP and coiled-coil domain-containing protein 2 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:4641245
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:78759
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_005497267.2 RNA Sequence

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