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Fmnl1 formin-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287746, updated on 9-Dec-2024

Summary

Official Symbol
Fmnl1provided by RGD
Official Full Name
formin-like 1provided by RGD
Primary source
RGD:1311042
See related
EnsemblRapid:ENSRNOG00000003207 AllianceGenome:RGD:1311042
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including GTPase activating protein binding activity; profilin binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including actin filament severing; cortical actin cytoskeleton organization; and regulation of cell shape. Predicted to act upstream of or within substrate-dependent cell migration. Predicted to be located in phagocytic vesicle and plasma membrane. Predicted to be active in cytosol. Orthologous to human FMNL1 (formin like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 168.6), Thymus (RPKM 123.2) and 7 other tissues See more
Orthologs
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Genomic context

See Fmnl1 in Genome Data Viewer
Location:
10q32.1
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88615290..88643411)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88115876..88143342)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91253757..91281422)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene HEXIM P-TEFb complex subunit 1 Neighboring gene HEXIM P-TEFb complex subunit 2 Neighboring gene EF-hand calcium binding domain 15 Neighboring gene spermatogenesis associated 32 Neighboring gene uncharacterized LOC120095296 Neighboring gene mitogen-activated protein kinase kinase kinase 14

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activating protein binding  
enables actin filament binding  
enables actin filament binding  
enables profilin binding  
enables small GTPase binding  
Process Evidence Code Pubs
involved_in actin filament severing  
involved_in cell migration  
involved_in cortical actin cytoskeleton organization  
involved_in cortical actin cytoskeleton organization  
involved_in regulation of cell shape  
involved_in regulation of cell shape  
acts_upstream_of_or_within substrate-dependent cell migration  
Component Evidence Code Pubs
is_active_in cytosol  
located_in cytosol  
located_in phagocytic vesicle  
located_in plasma membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105846.1NP_001099316.1  formin-like protein 1

    See identical proteins and their annotated locations for NP_001099316.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HJQ3, A6HJQ4, D3ZAZ1
    Related
    ENSRNOP00000062888.1, ENSRNOT00000065373.4
    Conserved Domains (3) summary
    pfam02181
    Location:572937
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:233406
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28154
    Drf_GBD; Diaphanous GTPase-binding Domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    88615290..88643411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247499.5XP_006247561.1  formin-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYX6
    Related
    ENSRNOP00000083255.2, ENSRNOT00000118615.2
    Conserved Domains (3) summary
    pfam02181
    Location:6351000
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:289469
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28286
    Drf_GBD; Diaphanous GTPase-binding Domain
  2. XM_006247498.5XP_006247560.1  formin-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYU6, A6HJQ3
    Conserved Domains (3) summary
    pfam02181
    Location:6351000
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:289469
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28286
    Drf_GBD; Diaphanous GTPase-binding Domain
  3. XM_063268750.1XP_063124820.1  formin-like protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZYX6, A0A8I6A0N3
    Related
    ENSRNOP00000084134.1, ENSRNOT00000110316.2
  4. XM_006247500.5XP_006247562.1  formin-like protein 1 isoform X3

    UniProtKB/TrEMBL
    A6HJQ3
    Related
    ENSRNOP00000070794.2, ENSRNOT00000087218.3
    Conserved Domains (3) summary
    pfam02181
    Location:629994
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:283463
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28280
    Drf_GBD; Diaphanous GTPase-binding Domain
  5. XM_008768266.4XP_008766488.1  formin-like protein 1 isoform X7

    UniProtKB/TrEMBL
    A6HJQ3
    Related
    ENSRNOP00000107106.1, ENSRNOT00000122620.1
    Conserved Domains (3) summary
    pfam02181
    Location:587952
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:241421
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28238
    Drf_GBD; Diaphanous GTPase-binding Domain
  6. XM_006247502.5XP_006247564.1  formin-like protein 1 isoform X4

    UniProtKB/TrEMBL
    A6HJQ3
    Conserved Domains (3) summary
    pfam02181
    Location:625990
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:279459
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28276
    Drf_GBD; Diaphanous GTPase-binding Domain
  7. XM_063268751.1XP_063124821.1  formin-like protein 1 isoform X6

    UniProtKB/TrEMBL
    A6HJQ3
  8. XM_008768267.4XP_008766489.1  formin-like protein 1 isoform X8

    UniProtKB/TrEMBL
    A6HJQ3
    Conserved Domains (3) summary
    pfam02181
    Location:577942
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:231411
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:28228
    Drf_GBD; Diaphanous GTPase-binding Domain
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