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Mpdz multiple PDZ domain crumbs cell polarity complex component [ Rattus norvegicus (Norway rat) ]

Gene ID: 29365, updated on 9-Dec-2024

Summary

Official Symbol
Mpdzprovided by RGD
Official Full Name
multiple PDZ domain crumbs cell polarity complex componentprovided by RGD
Primary source
RGD:3105
See related
EnsemblRapid:ENSRNOG00000007894 AllianceGenome:RGD:3105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in myelination. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human MPDZ (multiple PDZ domain crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Muscle (RPKM 147.0), Heart (RPKM 118.1) and 9 other tissues See more
Orthologs
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Genomic context

See Mpdz in Genome Data Viewer
Location:
5q31
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (100812121..100966566, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (95766112..95920531, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (99413184..99566356, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350991 Neighboring gene protein PRRC2C-like Neighboring gene uncharacterized LOC134479002 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion  
involved_in dendrite development  
involved_in intracellular protein transport  
involved_in intracellular signal transduction PubMed 
involved_in myelination PubMed 
involved_in tight junction assembly  
Component Evidence Code Pubs
located_in Schmidt-Lanterman incisure  
is_active_in apical part of cell  
located_in apical plasma membrane  
located_in apical plasma membrane  
located_in apicolateral plasma membrane  
located_in apicolateral plasma membrane  
is_active_in bicellular tight junction  
located_in bicellular tight junction  
located_in bicellular tight junction  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in cytoplasmic vesicle  
located_in dendrite  
located_in endomembrane system  
is_active_in glutamatergic synapse PubMed 
is_active_in plasma membrane  
is_active_in postsynaptic density PubMed 
part_of subapical complex  
is_active_in synapse  

General protein information

Preferred Names
multiple PDZ domain protein
Names
multi-PDZ domain protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429635.1NP_001416564.1  multiple PDZ domain protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K2Y8, A0A8I6AGX6
  2. NM_001429636.1NP_001416565.1  multiple PDZ domain protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6GLE5, A0A8L2QPJ0
  3. NM_019196.2NP_062069.1  multiple PDZ domain protein isoform 2

    See identical proteins and their annotated locations for NP_062069.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    O55164
    UniProtKB/TrEMBL
    A0A8I6AGX6, A6J832
    Related
    ENSRNOP00000107991.1, ENSRNOT00000154665.1
    Conserved Domains (4) summary
    pfam09045
    Location:663
    L27_2; L27_2
    smart00228
    Location:374463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:11361227
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16667
    Location:15491610
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    100812121..100966566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287256.1XP_063143326.1  multiple PDZ domain protein isoform X10

    UniProtKB/TrEMBL
    A0A8I6GLE5
  2. XM_063287255.1XP_063143325.1  multiple PDZ domain protein isoform X7

    UniProtKB/TrEMBL
    A0A8I6GLE5
    Related
    ENSRNOP00000095980.2, ENSRNOT00000108047.2
  3. XM_006238342.5XP_006238404.1  multiple PDZ domain protein isoform X5

    UniProtKB/TrEMBL
    A0A8I6GLE5
    Conserved Domains (4) summary
    pfam09045
    Location:663
    L27_2; L27_2
    smart00228
    Location:374463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:11111202
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16667
    Location:15241585
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein
  4. XM_039109364.2XP_038965292.1  multiple PDZ domain protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6AGX6
    Conserved Domains (4) summary
    smart00228
    Location:374463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:11321223
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:663
    L27_2
    pfam16667
    Location:15451606
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein
  5. XM_039109365.2XP_038965293.1  multiple PDZ domain protein isoform X9

    UniProtKB/TrEMBL
    A0A8I6AAR0, A0A8I6GLE5
    Conserved Domains (4) summary
    smart00228
    Location:374463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:19001983
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:663
    L27_2
    pfam16667
    Location:14791540
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein
  6. XM_006238343.5XP_006238405.1  multiple PDZ domain protein isoform X6

    Conserved Domains (4) summary
    pfam09045
    Location:663
    L27_2; L27_2
    smart00228
    Location:374463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:11361227
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16667
    Location:15161577
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein
  7. XM_006238344.5XP_006238406.1  multiple PDZ domain protein isoform X8

    UniProtKB/TrEMBL
    A0A8I6GLE5
    Related
    ENSRNOP00000088952.2, ENSRNOT00000105796.2
    Conserved Domains (4) summary
    pfam09045
    Location:663
    L27_2; L27_2
    smart00228
    Location:374463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:19141997
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16667
    Location:14931554
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein
  8. XM_006238341.5XP_006238403.1  multiple PDZ domain protein isoform X4

    UniProtKB/TrEMBL
    A0A8I6GLE5
    Related
    ENSRNOP00000051321.5, ENSRNOT00000051028.5
    Conserved Domains (4) summary
    pfam09045
    Location:663
    L27_2; L27_2
    smart00228
    Location:374463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:11501241
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16667
    Location:15301591
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein
  9. XM_039109363.2XP_038965291.1  multiple PDZ domain protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6AGX6
    Conserved Domains (4) summary
    smart00228
    Location:374463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:11501241
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09045
    Location:663
    L27_2
    pfam16667
    Location:15631624
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein
  10. XM_006238340.5XP_006238402.1  multiple PDZ domain protein isoform X1

    Related
    ENSRNOP00000072433.1, ENSRNOT00000089235.3
    Conserved Domains (4) summary
    pfam09045
    Location:663
    L27_2; L27_2
    smart00228
    Location:374463
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:11501241
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16667
    Location:15631624
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein
  11. XM_039109366.2XP_038965294.1  multiple PDZ domain protein isoform X11

    Conserved Domains (3) summary
    smart00228
    Location:763847
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:288379
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16667
    Location:701762
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein
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