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Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29747, updated on 9-Dec-2024

Summary

Official Symbol
Kcnmb1provided by RGD
Official Full Name
potassium calcium-activated channel subfamily M regulatory beta subunit 1provided by RGD
Primary source
RGD:2961
See related
EnsemblRapid:ENSRNOG00000005465 AllianceGenome:RGD:2961
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BKbeta; BKbeta1; slo-beta; slo-beta-1; k(VCA)beta-1
Summary
Enables potassium channel regulator activity. Involved in several processes, including cellular response to bile acid; cellular response to ethanol; and cellular response to hypoxia. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Used to study hypertension. Biomarker of hypertension and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Uterus (RPKM 45.2), Kidney (RPKM 10.4) and 5 other tissues See more
Orthologs
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Genomic context

See Kcnmb1 in Genome Data Viewer
Location:
10q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (19062014..19119005)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (18557510..18614824)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (18910586..18922856)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel interacting protein 1 Neighboring gene large ribosomal subunit protein eL29-like Neighboring gene uncharacterized LOC120095245 Neighboring gene uncharacterized LOC134480773 Neighboring gene lymphocyte cytosolic protein 2 Neighboring gene similar to human chromosome 5 open reading frame 58

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in membrane  
located_in plasma membrane  
part_of voltage-gated potassium channel complex  
part_of voltage-gated potassium channel complex  

General protein information

Preferred Names
calcium-activated potassium channel subunit beta-1
Names
BK channel subunit beta-1
calcium-activated potassium channel beta subunit
calcium-activated potassium channel subunit beta
calcium-activated potassium channel, subfamily M subunit beta-1
charybdotoxin receptor subunit beta-1
maxi K channel subunit beta-1
potassium channel subfamily M regulatory beta subunit 1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
slowpoke-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019273.1 → NP_062146.1  calcium-activated potassium channel subunit beta-1

    See identical proteins and their annotated locations for NP_062146.1

    Status: PROVISIONAL

    Source sequence(s)
    AF020712
    UniProtKB/Swiss-Prot
    O35337, O88805, P97678, Q9ESK7, Q9QWI7
    UniProtKB/TrEMBL
    A6HDH5, B5U130
    Related
    ENSRNOP00000103628.1, ENSRNOT00000159821.1
    Conserved Domains (1) summary
    pfam03185
    Location:7 → 190
    CaKB; Calcium-activated potassium channel, beta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    19062014..19119005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085796.2 → XP_038941724.1  calcium-activated potassium channel subunit beta-1 isoform X2

    Conserved Domains (1) summary
    pfam03185
    Location:7 → 102
    CaKB; Calcium-activated potassium channel, beta subunit
  2. XM_039085797.2 → XP_038941725.1  calcium-activated potassium channel subunit beta-1 isoform X3

    UniProtKB/TrEMBL
    A6HDH4
    Related
    ENSRNOP00000071161.2, ENSRNOT00000090659.3
    Conserved Domains (1) summary
    pfam03185
    Location:7 → 126
    CaKB; Calcium-activated potassium channel, beta subunit
  3. XM_006246089.5 → XP_006246151.1  calcium-activated potassium channel subunit beta-1 isoform X1

    See identical proteins and their annotated locations for XP_006246151.1

    UniProtKB/Swiss-Prot
    O35337, O88805, P97678, Q9ESK7, Q9QWI7
    UniProtKB/TrEMBL
    A6HDH5, B5U130
    Conserved Domains (1) summary
    pfam03185
    Location:7 → 190
    CaKB; Calcium-activated potassium channel, beta subunit
  4. XM_063268844.1 → XP_063124914.1  calcium-activated potassium channel subunit beta-1 isoform X3

    UniProtKB/TrEMBL
    A6HDH4
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