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    Jdp2 Jun dimerization protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116674, updated on 9-Dec-2024

    Summary

    Official Symbol
    Jdp2provided by RGD
    Official Full Name
    Jun dimerization protein 2provided by RGD
    Primary source
    RGD:621611
    See related
    EnsemblRapid:ENSRNOG00000063964 AllianceGenome:RGD:621611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Jundm2; Jundp2
    Summary
    Enables DNA-binding transcription factor activity and double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human JDP2 (Jun dimerization protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 60.0), Brain (RPKM 54.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Jdp2 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110988927..111033392)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (105261619..105302386)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109464910..109505591)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479234 Neighboring gene Fos proto-oncogene, AP-1 transcription factor subunit Neighboring gene uncharacterized LOC108351275 Neighboring gene basic leucine zipper ATF-like transcription factor Neighboring gene uncharacterized LOC120103579 Neighboring gene FLVCR choline and putative heme transporter 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA binding  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables cAMP response element binding  
    enables chromatin binding  
    enables double-stranded DNA binding PubMed 
    enables histone chaperone activity  
    enables histone deacetylase binding  
    enables leucine zipper domain binding  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein-containing complex binding PubMed 
    enables sequence-specific double-stranded DNA binding  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    is_active_in nucleus  
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053894.3NP_446346.1  jun dimerization protein 2

      See identical proteins and their annotated locations for NP_446346.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q78E65
      UniProtKB/TrEMBL
      A6JE34
      Related
      ENSRNOP00000108516.1, ENSRNOT00000139861.1
      Conserved Domains (3) summary
      cd14686
      Location:82132
      bZIP; coiled coil [structural motif]
      cl21453
      Location:1861
      PKc_like; Protein Kinases, catalytic domain
      cl21462
      Location:82135
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      110988927..111033392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764734.4XP_008762956.1  jun dimerization protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008762956.1

      UniProtKB/TrEMBL
      A0A8I6GCN6, A6JE33
      Related
      ENSRNOP00000085253.1, ENSRNOT00000115379.2
      Conserved Domains (2) summary
      cd14722
      Location:231284
      bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
      cl21453
      Location:167210
      PKc_like; Protein Kinases, catalytic domain
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