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Osbpl1a oxysterol binding protein-like 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 259221, updated on 9-Dec-2024

Summary

Official Symbol
Osbpl1aprovided by RGD
Official Full Name
oxysterol binding protein-like 1Aprovided by RGD
Primary source
RGD:628888
See related
EnsemblRapid:ENSRNOG00000054058 AllianceGenome:RGD:628888
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cholesterol binding activity. Predicted to be involved in lipid transport. Predicted to be located in late endosome and organelle membrane contact site. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Orthologous to human OSBPL1A (oxysterol binding protein like 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 361.3), Kidney (RPKM 326.6) and 9 other tissues See more
Orthologs
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Genomic context

See Osbpl1a in Genome Data Viewer
Location:
18p13
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (4178734..4383511, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (3904006..4094635, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (4097011..4294136, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene uncharacterized LOC134482904 Neighboring gene calcium binding tyrosine phosphorylation regulated Neighboring gene uncharacterized LOC102546723 Neighboring gene oxysterol binding protein-like 1A like Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene impact RWD domain protein Neighboring gene histamine receptor H4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cholesterol binding  
enables cholesterol binding  
enables lipid binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in lipid transport  
Component Evidence Code Pubs
is_active_in cytosol  
located_in endosome  
located_in late endosome  
located_in late endosome  
located_in late endosome  
located_in organelle membrane contact site  
located_in organelle membrane contact site  
is_active_in perinuclear endoplasmic reticulum  
is_active_in plasma membrane  

General protein information

Preferred Names
oxysterol-binding protein-related protein 1
Names
ORP-1
OSBP-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172023.1NP_742020.1  oxysterol-binding protein-related protein 1

    See identical proteins and their annotated locations for NP_742020.1

    Status: PROVISIONAL

    Source sequence(s)
    AB089316
    UniProtKB/Swiss-Prot
    Q8K4M9
    UniProtKB/TrEMBL
    A0A0G2K327
    Related
    ENSRNOP00000072477.2, ENSRNOT00000091909.3
    Conserved Domains (7) summary
    cd00204
    Location:43196
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13285
    Location:229352
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    pfam00169
    Location:239334
    PH; PH domain
    pfam01237
    Location:548934
    Oxysterol_BP; Oxysterol-binding protein
    pfam12796
    Location:10111
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:160216
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:4378
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    4178734..4383511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277125.1XP_063133195.1  oxysterol-binding protein-related protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K327
  2. XM_063277127.1XP_063133197.1  oxysterol-binding protein-related protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K327, A6KLS5
  3. XM_063277126.1XP_063133196.1  oxysterol-binding protein-related protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K327, A6KLS5
  4. XM_063277128.1XP_063133198.1  oxysterol-binding protein-related protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K327, A6KLS5
  5. XM_039096597.2XP_038952525.1  oxysterol-binding protein-related protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K327
    Conserved Domains (5) summary
    COG0666
    Location:38208
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd13285
    Location:230353
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:4378
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:549941
    Oxysterol_BP; Oxysterol-binding protein
    pfam12796
    Location:10111
    Ank_2; Ankyrin repeats (3 copies)
  6. XM_039096596.2XP_038952524.1  oxysterol-binding protein-related protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K327
    Conserved Domains (5) summary
    COG0666
    Location:38208
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd13285
    Location:230353
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:4378
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:549941
    Oxysterol_BP; Oxysterol-binding protein
    pfam12796
    Location:10111
    Ank_2; Ankyrin repeats (3 copies)
  7. XM_039096598.1XP_038952526.1  oxysterol-binding protein-related protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K327
    Related
    ENSRNOP00000109377.1, ENSRNOT00000162073.1
    Conserved Domains (4) summary
    cd13285
    Location:139262
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:4382
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:458850
    Oxysterol_BP; Oxysterol-binding protein
    pfam12796
    Location:10115
    Ank_2; Ankyrin repeats (3 copies)
  8. XM_063277129.1XP_063133199.1  oxysterol-binding protein-related protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K327
  9. XM_039096602.1XP_038952530.1  oxysterol-binding protein-related protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6GFS2
    Related
    ENSRNOP00000087195.1, ENSRNOT00000119742.2
    Conserved Domains (1) summary
    pfam01237
    Location:125517
    Oxysterol_BP; Oxysterol-binding protein
  10. XM_063277130.1XP_063133200.1  oxysterol-binding protein-related protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GFS2
  11. XM_039096601.2XP_038952529.1  oxysterol-binding protein-related protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6GFS2
    Conserved Domains (1) summary
    pfam01237
    Location:166558
    Oxysterol_BP; Oxysterol-binding protein
  12. XM_039096603.2XP_038952531.1  oxysterol-binding protein-related protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6GFS2
    Conserved Domains (1) summary
    pfam01237
    Location:125517
    Oxysterol_BP; Oxysterol-binding protein
  13. XM_063277132.1XP_063133202.1  oxysterol-binding protein-related protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I6GFS2
  14. XM_063277131.1XP_063133201.1  oxysterol-binding protein-related protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GFS2
  15. XM_039096606.2XP_038952534.1  oxysterol-binding protein-related protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A8I6GFS2, A6KLS6
    Conserved Domains (1) summary
    pfam01237
    Location:35427
    Oxysterol_BP; Oxysterol-binding protein
  16. XM_039096605.2XP_038952533.1  oxysterol-binding protein-related protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A8I6GFS2, A6KLS6
    Conserved Domains (1) summary
    pfam01237
    Location:35427
    Oxysterol_BP; Oxysterol-binding protein
  17. XM_063277133.1XP_063133203.1  oxysterol-binding protein-related protein 1 isoform X10

    UniProtKB/TrEMBL
    A6KLS7

RNA

  1. XR_010059548.1 RNA Sequence

  2. XR_010059549.1 RNA Sequence

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