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Srebf2 sterol regulatory element binding transcription factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300095, updated on 9-Dec-2024

Summary

Official Symbol
Srebf2provided by RGD
Official Full Name
sterol regulatory element binding transcription factor 2provided by RGD
Primary source
RGD:1307751
See related
EnsemblRapid:ENSRNOG00000007400 AllianceGenome:RGD:1307751
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SREBP2; SREBP-2; Srebf2_retired
Summary
Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of DNA-templated transcription; response to lead ion; and spermatogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in dendrite. Biomarker of kidney disease (multiple); lipid storage disease; obesity; and visual epilepsy. Human ortholog(s) of this gene implicated in carotid artery disease; diabetes mellitus (multiple); prostate cancer; sarcoma; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 184.6), Brain (RPKM 178.2) and 9 other tissues See more
Orthologs
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Genomic context

See Srebf2 in Genome Data Viewer
Location:
7q34
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115542774..115600945)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113663202..113720850)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123381082..123438605)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene meiotic double-stranded break formation protein 1 Neighboring gene uncharacterized LOC134479947 Neighboring gene coiled-coil domain containing 134 Neighboring gene microRNA 33 Neighboring gene shisa family member 8 Neighboring gene TNF receptor superfamily member 13C

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Clone Names

  • MGC124823

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables C-8 sterol isomerase activity  
enables DNA binding  
enables DNA-binding transcription factor activity  
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
enables E-box binding  
enables E-box binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables chromatin binding PubMed 
enables protein dimerization activity  
enables sequence-specific DNA binding PubMed 
enables sequence-specific double-stranded DNA binding  
enables transcription cis-regulatory region binding  
Items 1 - 25 of 41
Process Evidence Code Pubs
involved_in SREBP signaling pathway  
involved_in SREBP signaling pathway  
involved_in SREBP signaling pathway  
involved_in cellular response to low-density lipoprotein particle stimulus  
involved_in cellular response to low-density lipoprotein particle stimulus  
involved_in cellular response to starvation  
involved_in cellular response to starvation  
involved_in cholesterol homeostasis  
acts_upstream_of_or_within cholesterol homeostasis  
involved_in cholesterol metabolic process  
involved_in lipid biosynthetic process PubMed 
involved_in negative regulation of cholesterol efflux  
acts_upstream_of negative regulation of cholesterol efflux  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of cholesterol biosynthetic process  
involved_in positive regulation of cholesterol biosynthetic process  
involved_in positive regulation of cholesterol biosynthetic process  
involved_in positive regulation of cholesterol storage  
involved_in positive regulation of cholesterol storage  
acts_upstream_of positive regulation of cholesterol storage  
involved_in positive regulation of miRNA transcription  
involved_in positive regulation of miRNA transcription  
involved_in positive regulation of myelination  
involved_in positive regulation of protein targeting to mitochondrion PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within regulation of DNA-templated transcription  
involved_in regulation of Notch signaling pathway  
involved_in regulation of mitophagy PubMed 
involved_in regulation of transcription by RNA polymerase II  
involved_in regulation of transcription by RNA polymerase II  
involved_in response to hormone PubMed 
involved_in response to lead ion PubMed 
involved_in response to lipid PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in spermatogenesis PubMed 
Items 1 - 25 of 41
Component Evidence Code Pubs
located_in ER to Golgi transport vesicle membrane  
located_in Golgi membrane  
part_of SREBP-SCAP-Insig complex  
part_of SREBP-SCAP-Insig complex  
located_in cytoplasm  
located_in dendrite PubMed 
located_in endoplasmic reticulum  
located_in intracellular membrane-bounded organelle  
located_in membrane  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
is_active_in nucleus  
located_in nucleus  
located_in nucleus  

General protein information

Preferred Names
sterol regulatory element-binding protein 2
Names
sterol regulatory element binding factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033694.2NP_001028866.2  sterol regulatory element-binding protein 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q3T1I5
    UniProtKB/TrEMBL
    F1MA23
    Related
    ENSRNOP00000052893.2, ENSRNOT00000056041.4
    Conserved Domains (1) summary
    cd18922
    Location:318394
    bHLHzip_SREBP2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 2 (SREBP2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    115542774..115600945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263322.1XP_063119392.1  sterol regulatory element-binding protein 2 isoform X1

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