U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Tnpo1 transportin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309126, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnpo1provided by RGD
    Official Full Name
    transportin 1provided by RGD
    Primary source
    RGD:1308372
    See related
    EnsemblRapid:ENSRNOG00000014999 AllianceGenome:RGD:1308372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNPO1 (transportin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 275.3), Adrenal (RPKM 268.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tnpo1 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (31941731..32034366, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (30207529..30300162, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (29056219..29126882, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 171 Neighboring gene Histone deacetylase 1, pseudogene 8 Neighboring gene FCH and mu domain containing endocytic adaptor 2 Neighboring gene eukaryotic translation initiation factor 5B like Neighboring gene H2B.L histone variant 1 Neighboring gene uncharacterized LOC134485826

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity  
    enables nuclear localization sequence binding  
    enables small GTPase binding  
    Process Evidence Code Pubs
    involved_in protein import into nucleus  
    involved_in protein import into nucleus  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in nucleus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100692.2NP_001094162.1  transportin-1 isoform b

      See identical proteins and their annotated locations for NP_001094162.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AG33, F1LQP9
      Related
      ENSRNOP00000020543.8, ENSRNOT00000020543.9
      Conserved Domains (2) summary
      COG5215
      Location:24759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95116
      HEAT; HEAT repeat [structural motif]
    2. NM_001399431.1NP_001386360.1  transportin-1 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AK79
      Related
      ENSRNOP00000093625.2, ENSRNOT00000099589.2
      Conserved Domains (2) summary
      COG5215
      Location:32767
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:103124
      HEAT; HEAT repeat [structural motif]
    3. NM_001399432.1NP_001386361.1  transportin-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AG33, F1LQP9
      Related
      ENSRNOP00000092200.1, ENSRNOT00000110663.2
      Conserved Domains (2) summary
      COG5215
      Location:24759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95116
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      31941731..32034366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102145.2XP_038958073.1  transportin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AG33, F1LQP9
      Conserved Domains (2) summary
      COG5215
      Location:24759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95116
      HEAT; HEAT repeat [structural motif]
    2. XM_039102144.2XP_038958072.1  transportin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AG33, F1LQP9
      Conserved Domains (2) summary
      COG5215
      Location:24759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95116
      HEAT; HEAT repeat [structural motif]
    3. XM_006231840.5XP_006231902.1  transportin-1 isoform X1

      See identical proteins and their annotated locations for XP_006231902.1

      UniProtKB/TrEMBL
      A0A8I6AG33, F1LQP9
      Conserved Domains (2) summary
      COG5215
      Location:24759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95116
      HEAT; HEAT repeat [structural motif]
    4. XM_008760668.4XP_008758890.1  transportin-1 isoform X1

      See identical proteins and their annotated locations for XP_008758890.1

      UniProtKB/TrEMBL
      A0A8I6AG33, F1LQP9
      Conserved Domains (2) summary
      COG5215
      Location:24759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95116
      HEAT; HEAT repeat [structural motif]
    5. XM_063281688.1XP_063137758.1  transportin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AK79
    Loading
    Loading
    External link. Please review our privacy policy.