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    Myl1 myosin, light chain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56781, updated on 9-Dec-2024

    Summary

    Official Symbol
    Myl1provided by RGD
    Official Full Name
    myosin, light chain 1provided by RGD
    Primary source
    RGD:1598796
    See related
    EnsemblRapid:ENSRNOG00000013262 AllianceGenome:RGD:1598796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MLCf; Mcl3; Mlc1; Mlc3; MLC-f; MLC3-f
    Summary
    Predicted to be a structural constituent of muscle. Involved in cardiac muscle contraction. Located in contractile muscle fiber. Human ortholog(s) of this gene implicated in congenital myopathy 14. Orthologous to human MYL1 (myosin light chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 42414.1) See more
    Orthologs
    NEW
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    Genomic context

    See Myl1 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (75887224..75907696, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (68437514..68458256, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (73937820..73958480, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase, long chain Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC134480586 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene pumilio RNA-binding family member 3, pseudogene 2 Neighboring gene large ribosomal subunit protein eL32-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables structural constituent of muscle  
    enables structural constituent of muscle  
    enables structural constituent of muscle  
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction PubMed 
    involved_in muscle contraction  
    involved_in muscle contraction  
    Component Evidence Code Pubs
    is_active_in contractile muscle fiber  
    located_in contractile muscle fiber PubMed 
    located_in myofibril  
    located_in myofibril  
    part_of myosin II complex  
    part_of myosin complex  

    General protein information

    Preferred Names
    myosin light chain 1/3, skeletal muscle isoform
    Names
    MLC1/MLC3
    MLC1F
    MLC1F/MLC3F
    MLC3F
    alkali myosin light chain 1
    alkali myosin light chain 3
    fast myosin alkali light chain 1
    fast myosin alkali light chain 3
    myosin light chain A1/A2
    myosin light chain alkali 1/2
    myosin, light polypeptide 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077656.1NP_001071124.1  myosin light chain 1/3, skeletal muscle isoform isoform 1f

      See identical proteins and their annotated locations for NP_001071124.1

      Status: VALIDATED

      Source sequence(s)
      BI277595, CB809837, CR755322
      UniProtKB/Swiss-Prot
      P02600, P02601
      UniProtKB/TrEMBL
      A6KFD8
      Related
      ENSRNOP00000017838.3, ENSRNOT00000017838.8
      Conserved Domains (1) summary
      PTZ00184
      Location:40188
      PTZ00184; calmodulin; Provisional
    2. NM_020104.2NP_064489.1  myosin light chain 1/3, skeletal muscle isoform isoform 3f

      See identical proteins and their annotated locations for NP_064489.1

      Status: VALIDATED

      Source sequence(s)
      BI277595, CR756356
      UniProtKB/TrEMBL
      A0A8I6A453, A6KFD9
      Conserved Domains (1) summary
      PTZ00184
      Location:4149
      PTZ00184; calmodulin; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      75887224..75907696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767294.2XP_008765516.1  myosin light chain 1/3, skeletal muscle isoform isoform X1

      Related
      ENSRNOP00000086625.2, ENSRNOT00000112334.2
      Conserved Domains (3) summary
      PTZ00184
      Location:72211
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:149210
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:72136
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
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