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    Grin2a glutamate ionotropic receptor NMDA type subunit 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24409, updated on 9-Dec-2024

    Summary

    Official Symbol
    Grin2aprovided by RGD
    Official Full Name
    glutamate ionotropic receptor NMDA type subunit 2Aprovided by RGD
    Primary source
    RGD:2737
    See related
    EnsemblRapid:ENSRNOG00000033942 AllianceGenome:RGD:2737
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NR2A; GluN2A; NMDAR2A
    Summary
    Enables several functions, including enzyme binding activity; glutamate binding activity; and monoatomic ion channel activity. Contributes to extracellularly glutamate-gated ion channel activity and monoatomic cation channel activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of signal transduction. Located in several cellular components, including dendrite; postsynaptic density, intracellular component; and postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic membrane. Used to study hyperhomocysteinemia and transient cerebral ischemia. Biomarker of cognitive disorder; placental insufficiency; post-traumatic stress disorder; status epilepticus; and withdrawal disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; bipolar disorder; colorectal cancer; and heroin dependence. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 176.8) See more
    Orthologs
    NEW
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    Genomic context

    See Grin2a in Genome Data Viewer
    Location:
    10q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (6136458..6560003)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (5629683..6053262)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (5707806..6123568)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 like 1 Neighboring gene uncharacterized LOC108352053 Neighboring gene uncharacterized LOC120095022 Neighboring gene uncharacterized LOC134480648 Neighboring gene similar to 60S ribosomal protein L23a

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 40
    Function Evidence Code Pubs
    enables ATPase binding PubMed 
    enables NMDA glutamate receptor activity PubMed 
    enables NMDA glutamate receptor activity  
    enables NMDA glutamate receptor activity PubMed 
    contributes_to NMDA glutamate receptor activity  
    enables NMDA glutamate receptor activity  
    contributes_to calcium channel activity  
    enables calcium channel activity  
    enables calcium-dependent protein binding PubMed 
    enables cell adhesion molecule binding PubMed 
    contributes_to extracellularly glutamate-gated ion channel activity PubMed 
    enables glutamate binding PubMed 
    enables glutamate binding PubMed 
    enables glutamate receptor activity  
    enables glutamate receptor binding PubMed 
    enables glutamate-gated calcium ion channel activity  
    enables glutamate-gated calcium ion channel activity  
    enables glutamate-gated calcium ion channel activity  
    enables glutamate-gated receptor activity PubMed 
    contributes_to glutamate-gated receptor activity PubMed 
    enables glutamate-gated receptor activity PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential PubMed 
    enables metal ion binding  
    contributes_to monoatomic cation channel activity PubMed 
    enables monoatomic cation channel activity  
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables protein tyrosine kinase binding PubMed 
    enables protein-containing complex binding PubMed 
    enables protein-containing complex binding PubMed 
    enables scaffold protein binding PubMed 
    enables signaling receptor binding PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
    enables voltage-gated monoatomic cation channel activity PubMed 
    enables zinc ion binding PubMed 
    enables zinc ion binding  
    Items 1 - 25 of 40
    Items 1 - 25 of 129
    Process Evidence Code Pubs
    involved_in action potential PubMed 
    involved_in auditory behavior PubMed 
    involved_in calcium ion transmembrane import into cytosol  
    involved_in calcium ion transmembrane import into cytosol  
    involved_in calcium ion transmembrane import into cytosol  
    involved_in calcium ion transmembrane transport  
    acts_upstream_of_or_within calcium ion transport  
    involved_in calcium-mediated signaling  
    involved_in cellular response to amino acid stimulus PubMed 
    NOT involved_in cellular response to amyloid-beta  
    involved_in cellular response to dsRNA PubMed 
    involved_in cellular response to glycine PubMed 
    involved_in cellular response to growth factor stimulus PubMed 
    involved_in cellular response to lipid PubMed 
    involved_in cellular response to magnesium ion PubMed 
    involved_in cellular response to manganese ion PubMed 
    involved_in cellular response to zinc ion PubMed 
    involved_in cerebral cortex development PubMed 
    involved_in chemical synaptic transmission PubMed 
    acts_upstream_of_or_within chemical synaptic transmission  
    involved_in conditioned place preference PubMed 
    involved_in dendritic spine organization PubMed 
    NOT acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain  
    involved_in directional locomotion  
    acts_upstream_of_or_within directional locomotion  
    involved_in dopamine metabolic process  
    acts_upstream_of_or_within dopamine metabolic process  
    involved_in excitatory postsynaptic potential  
    involved_in excitatory postsynaptic potential  
    involved_in excitatory postsynaptic potential PubMed 
    acts_upstream_of_or_within excitatory postsynaptic potential  
    involved_in glutamate receptor signaling pathway  
    involved_in hippocampus development PubMed 
    involved_in ionotropic glutamate receptor signaling pathway PubMed 
    involved_in ionotropic glutamate receptor signaling pathway  
    involved_in ionotropic glutamate receptor signaling pathway  
    acts_upstream_of_or_within learning  
    acts_upstream_of_or_within learning or memory  
    acts_upstream_of_or_within locomotion  
    involved_in long-term synaptic potentiation  
    involved_in long-term synaptic potentiation  
    involved_in long-term synaptic potentiation PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation  
    involved_in memory PubMed 
    involved_in memory  
    acts_upstream_of_or_within memory  
    involved_in modulation of chemical synaptic transmission  
    involved_in modulation of excitatory postsynaptic potential PubMed 
    involved_in monoatomic cation transmembrane transport PubMed 
    involved_in monoatomic cation transmembrane transport  
    involved_in monoatomic cation transmembrane transport  
    involved_in multicellular organismal response to stress PubMed 
    involved_in negative regulation of protein catabolic process  
    acts_upstream_of_or_within negative regulation of protein catabolic process  
    involved_in neurogenesis  
    acts_upstream_of_or_within neurogenesis  
    involved_in neuron development PubMed 
    involved_in neurotransmitter receptor transport, plasma membrane to endosome PubMed 
    involved_in positive regulation of apoptotic process  
    acts_upstream_of_or_within positive regulation of apoptotic process  
    involved_in positive regulation of excitatory postsynaptic potential PubMed 
    involved_in positive regulation of excitatory postsynaptic potential PubMed 
    involved_in positive regulation of excitatory postsynaptic potential  
    involved_in positive regulation of inhibitory postsynaptic potential PubMed 
    involved_in positive regulation of protein targeting to membrane PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic  
    involved_in protein catabolic process  
    acts_upstream_of protein catabolic process  
    involved_in protein localization to postsynaptic membrane  
    acts_upstream_of_or_within protein localization to postsynaptic membrane  
    involved_in receptor recycling PubMed 
    involved_in regulation of ARF protein signal transduction PubMed 
    involved_in regulation of NMDA receptor activity PubMed 
    involved_in regulation of long-term neuronal synaptic plasticity PubMed 
    involved_in regulation of membrane potential PubMed 
    acts_upstream_of_or_within regulation of membrane potential  
    involved_in regulation of monoatomic cation transmembrane transport PubMed 
    involved_in regulation of monoatomic cation transmembrane transport  
    involved_in regulation of neuronal synaptic plasticity PubMed 
    acts_upstream_of_or_within regulation of postsynaptic membrane potential  
    involved_in regulation of presynaptic membrane potential  
    involved_in regulation of response to alcohol PubMed 
    involved_in regulation of synaptic plasticity  
    involved_in regulation of synaptic plasticity  
    involved_in response to amine PubMed 
    involved_in response to ammonium ion PubMed 
    involved_in response to amphetamine  
    acts_upstream_of_or_within response to amphetamine  
    involved_in response to calcium ion PubMed 
    involved_in response to carbohydrate PubMed 
    involved_in response to cocaine PubMed 
    involved_in response to environmental enrichment PubMed 
    involved_in response to ethanol  
    involved_in response to ethanol PubMed 
    involved_in response to ethanol PubMed 
    acts_upstream_of_or_within response to ethanol  
    involved_in response to ethanol  
    involved_in response to fungicide PubMed 
    involved_in response to hydrogen sulfide PubMed 
    involved_in response to lead ion PubMed 
    involved_in response to light stimulus PubMed 
    involved_in response to lithium ion PubMed 
    involved_in response to manganese ion PubMed 
    involved_in response to methylmercury PubMed 
    involved_in response to nicotine PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to other organism PubMed 
    involved_in response to wounding  
    acts_upstream_of_or_within response to wounding  
    involved_in response to xenobiotic stimulus  
    involved_in response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus  
    involved_in rhythmic process PubMed 
    involved_in sensory perception of pain  
    acts_upstream_of_or_within sensory perception of pain  
    involved_in serotonin metabolic process  
    acts_upstream_of_or_within serotonin metabolic process  
    involved_in sleep  
    acts_upstream_of_or_within sleep  
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transmembrane transport  
    involved_in spinal cord development PubMed 
    involved_in startle response  
    NOT acts_upstream_of_or_within startle response  
    acts_upstream_of_or_within startle response  
    involved_in synaptic transmission, glutamatergic  
    involved_in visual learning  
    acts_upstream_of_or_within visual learning  
    Items 1 - 25 of 129
    Items 1 - 20 of 51
    Component Evidence Code Pubs
    part_of NMDA selective glutamate receptor complex  
    part_of NMDA selective glutamate receptor complex PubMed 
    part_of NMDA selective glutamate receptor complex  
    part_of NMDA selective glutamate receptor complex  
    part_of NMDA selective glutamate receptor complex  
    located_in cell surface PubMed 
    located_in cell surface  
    located_in cell surface  
    located_in cytoplasm PubMed 
    located_in cytoplasmic vesicle membrane  
    located_in dendrite membrane PubMed 
    located_in dendritic spine PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in membrane  
    located_in neuron projection PubMed 
    located_in neuron projection  
    located_in neuron projection  
    is_active_in parallel fiber to Purkinje cell synapse PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynapse  
    located_in postsynaptic density PubMed 
    is_active_in postsynaptic density  
    located_in postsynaptic density  
    is_active_in postsynaptic density membrane  
    located_in postsynaptic density membrane  
    is_active_in postsynaptic density membrane  
    located_in postsynaptic density, intracellular component PubMed 
    located_in postsynaptic membrane PubMed 
    located_in postsynaptic membrane  
    located_in postsynaptic membrane PubMed 
    is_active_in presynaptic membrane PubMed 
    located_in presynaptic membrane PubMed 
    located_in presynaptic membrane  
    located_in presynaptic membrane  
    located_in synapse  
    located_in synapse PubMed 
    located_in synaptic membrane  
    located_in synaptic vesicle  
    located_in synaptic vesicle  
    located_in terminal bouton PubMed 
    Items 1 - 20 of 51

    General protein information

    Preferred Names
    glutamate receptor ionotropic, NMDA 2A
    Names
    N-methyl D-aspartate receptor subtype 2A
    N-methyl-D-aspartate receptor subunit 2A
    glutamate [NMDA] receptor subunit epsilon-1
    glutamate receptor, ionotropic, N-methyl D-aspartate 2A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012573.4NP_036705.3  glutamate receptor ionotropic, NMDA 2A precursor

      See identical proteins and their annotated locations for NP_036705.3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010, M91561
      UniProtKB/Swiss-Prot
      O08948, Q00959, Q63728
      UniProtKB/TrEMBL
      A6K4L3, G3V9C5
      Related
      ENSRNOP00000042235.4, ENSRNOT00000044626.5
      Conserved Domains (5) summary
      cd06378
      Location:32392
      PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      COG0834
      Location:458541
      HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
      cd13718
      Location:403802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:556828
      Lig_chan; Ligand-gated ion channel
      pfam10565
      Location:8391464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      6136458..6560003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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