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    Gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114711, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gneprovided by RGD
    Official Full Name
    glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinaseprovided by RGD
    Primary source
    RGD:69239
    See related
    EnsemblRapid:ENSRNOG00000014365 AllianceGenome:RGD:69239
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Uae1
    Summary
    Enables N-acylmannosamine kinase activity and UDP-N-acetylglucosamine 2-epimerase activity. Predicted to be involved in CMP-N-acetylneuraminate biosynthetic process; N-acetylneuraminate biosynthetic process; and glycosylation. Is active in cytosol. Human ortholog(s) of this gene implicated in GNE myopathy; sialuria; and thrombocytopenia. Orthologous to human GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 304.5), Spleen (RPKM 79.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Gne in Genome Data Viewer
    Location:
    5q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (63062953..63103320, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (58267189..58307396, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (59511738..59553421, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene calicin Neighboring gene clathrin, light chain A Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene ring finger protein 38

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables N-acylmannosamine kinase activity  
    enables N-acylmannosamine kinase activity PubMed 
    enables N-acylmannosamine kinase activity  
    enables N-acylmannosamine kinase activity  
    enables UDP-N-acetylglucosamine 2-epimerase activity  
    enables UDP-N-acetylglucosamine 2-epimerase activity PubMed 
    enables UDP-N-acetylglucosamine 2-epimerase activity  
    enables UDP-N-acetylglucosamine 2-epimerase activity  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds  
    enables metal ion binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol PubMed 
    is_active_in cytosol  

    General protein information

    Preferred Names
    bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
    Names
    UDP-GlcNAc-2-epimerase/ManAc kinase
    UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
    NP_446217.1
    XP_006238068.1
    XP_006238070.1
    XP_006238071.1
    XP_038965053.1
    XP_038965055.1
    XP_063143130.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053765.3NP_446217.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

      See identical proteins and their annotated locations for NP_446217.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      O35826
      UniProtKB/TrEMBL
      A0A8I5ZWN3, A6IJ68
      Related
      ENSRNOP00000019532.3, ENSRNOT00000019532.7
      Conserved Domains (2) summary
      COG1940
      Location:409722
      NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
      TIGR03568
      Location:11374
      NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      63062953..63103320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238006.5XP_006238068.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X1

      See identical proteins and their annotated locations for XP_006238068.1

      UniProtKB/TrEMBL
      A0A0G2K7T2, A0A8I5ZWN3, A6IJ67
      Related
      ENSRNOP00000074334.1, ENSRNOT00000090490.3
      Conserved Domains (4) summary
      cd03786
      Location:42406
      GT1_UDP-GlcNAc_2-Epimerase; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues ...
      COG1940
      Location:440753
      NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
      TIGR03568
      Location:42405
      NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
      cl17037
      Location:441719
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. XM_006238008.3XP_006238070.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X2

      See identical proteins and their annotated locations for XP_006238070.1

      UniProtKB/Swiss-Prot
      O35826
      UniProtKB/TrEMBL
      A0A8I5ZWN3, A6IJ68
      Related
      ENSRNOP00000083164.1, ENSRNOT00000116467.2
      Conserved Domains (2) summary
      COG1940
      Location:409722
      NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
      TIGR03568
      Location:11374
      NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
    3. XM_039109125.2XP_038965053.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X2

      UniProtKB/Swiss-Prot
      O35826
      UniProtKB/TrEMBL
      A0A8I5ZWN3, A6IJ68
      Conserved Domains (2) summary
      COG1940
      Location:409722
      NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
      TIGR03568
      Location:11374
      NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
    4. XM_006238009.5XP_006238071.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X2

      See identical proteins and their annotated locations for XP_006238071.1

      UniProtKB/Swiss-Prot
      O35826
      UniProtKB/TrEMBL
      A0A8I5ZWN3, A6IJ68
      Conserved Domains (2) summary
      COG1940
      Location:409722
      NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
      TIGR03568
      Location:11374
      NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
    5. XM_039109127.2XP_038965055.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X2

      UniProtKB/Swiss-Prot
      O35826
      UniProtKB/TrEMBL
      A0A8I5ZWN3, A6IJ68
      Conserved Domains (2) summary
      COG1940
      Location:409722
      NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
      TIGR03568
      Location:11374
      NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
    6. XM_063287060.1XP_063143130.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X3

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