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Map3k1 mitogen-activated protein kinase kinase kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116667, updated on 27-Dec-2024

Summary

Symbol
Map3k1provided by RGD
Full Name
mitogen-activated protein kinase kinase kinase 1provided by RGD
Primary source
RGD:620966
See related
EnsemblRapid:ENSRNOG00000013177 AllianceGenome:RGD:620966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mekk1
Summary
Enables several functions, including JUN kinase kinase kinase activity; protein kinase binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including positive regulation of signal transduction; positive regulation of viral transcription; and protein modification process. Predicted to be located in tight junction. Predicted to be part of filamentous actin. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6; breast cancer; gastrointestinal system cancer (multiple); and lung non-small cell carcinoma. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 167.6), Kidney (RPKM 149.1) and 9 other tissues See more
Orthologs
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Genomic context

See Map3k1 in Genome Data Viewer
Location:
2q14
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (45081889..45150555, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (43348572..43414706, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (43329516..43393203, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485836 Neighboring gene SET domain containing, pseudogene 1 Neighboring gene uncharacterized LOC102553935 Neighboring gene uncharacterized LOC102554057

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables JUN kinase binding PubMed 
enables JUN kinase kinase kinase activity PubMed 
enables JUN kinase kinase kinase activity  
enables MAP kinase kinase activity  
enables MAP kinase kinase kinase activity PubMed 
enables cytoskeletal protein binding  
enables mitogen-activated protein kinase binding PubMed 
enables mitogen-activated protein kinase kinase binding PubMed 
enables protein binding PubMed 
enables protein kinase activity  
enables protein kinase binding  
enables protein kinase binding  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein-containing complex binding PubMed 
enables sphingolipid binding PubMed 
enables ubiquitin-protein transferase activity PubMed 
enables zinc ion binding  
Items 1 - 25 of 30
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade  
involved_in MAPK cascade PubMed 
acts_upstream_of_or_within apoptotic mitochondrial changes  
acts_upstream_of_or_within camera-type eye development  
involved_in cellular response to mechanical stimulus  
involved_in cellular response to mechanical stimulus  
acts_upstream_of_or_within epithelial cell morphogenesis  
acts_upstream_of_or_within eyelid development in camera-type eye  
acts_upstream_of_or_within morphogenesis of an epithelial sheet  
involved_in negative regulation of actin filament bundle assembly PubMed 
involved_in peptidyl-serine phosphorylation PubMed 
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of JNK cascade PubMed 
involved_in positive regulation of JUN kinase activity PubMed 
involved_in positive regulation of JUN kinase activity  
involved_in positive regulation of MAP kinase activity PubMed 
involved_in positive regulation of MAPK cascade PubMed 
acts_upstream_of_or_within positive regulation of actin filament polymerization  
involved_in positive regulation of apoptotic process PubMed 
involved_in positive regulation of canonical Wnt signaling pathway PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of viral transcription PubMed 
involved_in protein autophosphorylation PubMed 
involved_in protein autophosphorylation PubMed 
involved_in protein phosphorylation PubMed 
involved_in protein polyubiquitination PubMed 
acts_upstream_of_or_within regulation of cell migration  
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway  
involved_in ubiquitin-dependent protein catabolic process PubMed 
acts_upstream_of_or_within wound healing  
Items 1 - 25 of 30
Component Evidence Code Pubs
is_active_in cytoplasm  
part_of filamentous actin  
located_in membrane  
located_in tight junction  
located_in tight junction  

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 1
Names
MAPK/ERK kinase kinase 1
MEK kinase 1
MEKK 1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
NP_446339.2
XP_038957510.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053887.2NP_446339.2  mitogen-activated protein kinase kinase kinase 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    F1M778, H9BFG7
    Related
    ENSRNOP00000088035.2, ENSRNOT00000114100.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    45081889..45150555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101582.2XP_038957510.1  mitogen-activated protein kinase kinase kinase 1 isoform X1

    UniProtKB/TrEMBL
    F1M778, H9BFG7
    Conserved Domains (2) summary
    cd06630
    Location:12231490
    STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
    cd16494
    Location:430485
    RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
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