U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    En2 engrailed homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499964, updated on 9-Dec-2024

    Summary

    Official Symbol
    En2provided by RGD
    Official Full Name
    engrailed homeobox 2provided by RGD
    Primary source
    RGD:1561842
    See related
    EnsemblRapid:ENSRNOG00000006846 AllianceGenome:RGD:1561842
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561842
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic brain development; negative regulation of neuron apoptotic process; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nervous system development and positive regulation of transcription by RNA polymerase II. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 31.3), Kidney (RPKM 11.8) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See En2 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (7954953..7960793, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (7221096..7226943, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (438668..444508)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486706 Neighboring gene RNA binding motif protein 33 Neighboring gene canopy FGF signaling regulator 1 Neighboring gene uncharacterized LOC134486707 Neighboring gene uncharacterized LOC102546740 Neighboring gene insulin induced gene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in fibrillar center  
    located_in fibrillar center  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    homeobox protein engrailed-2
    Names
    engrailed 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109214.1NP_001102684.1  homeobox protein engrailed-2

      See identical proteins and their annotated locations for NP_001102684.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474057
      UniProtKB/TrEMBL
      A6KJL2, D3Z8B1
      Related
      ENSRNOP00000008951.3, ENSRNOT00000008951.7
      Conserved Domains (2) summary
      pfam00046
      Location:237290
      Homeobox; Homeobox domain
      pfam10525
      Location:292321
      Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      7954953..7960793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Loading
    External link. Please review our privacy policy.