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Miga1 mitoguardin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362058, updated on 9-Dec-2024

Summary

Official Symbol
Miga1provided by RGD
Official Full Name
mitoguardin 1provided by RGD
Primary source
RGD:1559958
See related
EnsemblRapid:ENSRNOG00000056332 AllianceGenome:RGD:1559958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam73a; RGD1559958
Summary
Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in mitochondrial fusion. Predicted to be located in mitochondrion and plasma membrane. Orthologous to human MIGA1 (mitoguardin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 134.4), Kidney (RPKM 41.4) and 8 other tissues See more
Orthologs
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Genomic context

See Miga1 in Genome Data Viewer
Location:
2q45
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243884071..243939059, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241224118..241279174, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257490729..257546846, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene far upstream element binding protein 1 Neighboring gene transmembrane protein 256, pseudogene 2 Neighboring gene nexilin (F actin binding protein) Neighboring gene uncharacterized LOC120100974 Neighboring gene ubiquitin specific peptidase 33 Neighboring gene zinc finger, ZZ-type containing 3 Neighboring gene uncharacterized LOC134485695 Neighboring gene adenylate kinase 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mitochondrial fusion  
involved_in mitochondrial fusion  
Component Evidence Code Pubs
located_in mitochondrial outer membrane  
located_in mitochondrion  
located_in plasma membrane  

General protein information

Preferred Names
mitoguardin 1
Names
family with sequence similarity 73, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433179.1NP_001420108.1  mitoguardin 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6HWL1, D4A5P3
  2. NM_001433180.1NP_001420109.1  mitoguardin 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6ADJ1, A6HWL1, D4A5P3
  3. NM_001433181.1NP_001420110.1  mitoguardin 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6ADJ1, A6HWL1, D4A5P3
  4. NM_001433182.1NP_001420111.1  mitoguardin 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
  5. NM_001433183.1NP_001420112.1  mitoguardin 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
  6. NM_001433187.1NP_001420116.1  mitoguardin 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    243884071..243939059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103886.2XP_038959814.1  mitoguardin 1 isoform X4

    Related
    ENSRNOP00000090920.2, ENSRNOT00000095768.2
    Conserved Domains (1) summary
    pfam10265
    Location:27571
    Miga; Mitoguardin
  2. XM_039103885.2XP_038959813.1  mitoguardin 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K2T2, A6HWL1, D4A5P3
    Related
    ENSRNOP00000072364.2, ENSRNOT00000089370.3
    Conserved Domains (1) summary
    pfam10265
    Location:27572
    Miga; Mitoguardin
  3. XM_039103884.2XP_038959812.1  mitoguardin 1 isoform X2

    Conserved Domains (1) summary
    pfam10265
    Location:27581
    Miga; Mitoguardin
  4. XM_039103882.2XP_038959810.1  mitoguardin 1 isoform X1

    UniProtKB/TrEMBL
    A6HWL1, D4A5P3
    Conserved Domains (1) summary
    pfam10265
    Location:27582
    Miga; Mitoguardin
  5. XM_063282753.1XP_063138823.1  mitoguardin 1 isoform X4

  6. XM_063282752.1XP_063138822.1  mitoguardin 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K2T2, A6HWL1, D4A5P3
  7. XM_039103883.2XP_038959811.1  mitoguardin 1 isoform X1

    UniProtKB/TrEMBL
    A6HWL1, D4A5P3
    Conserved Domains (1) summary
    pfam10265
    Location:27582
    Miga; Mitoguardin
  8. XM_039103889.2XP_038959817.1  mitoguardin 1 isoform X6

    Conserved Domains (1) summary
    pfam10265
    Location:27265
    Miga; Mitoguardin
  9. XM_063282755.1XP_063138825.1  mitoguardin 1 isoform X6

  10. XM_063282754.1XP_063138824.1  mitoguardin 1 isoform X5

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