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Ppp1r1a protein phosphatase 1, regulatory (inhibitor) subunit 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 58977, updated on 9-Dec-2024

Summary

Official Symbol
Ppp1r1aprovided by RGD
Official Full Name
protein phosphatase 1, regulatory (inhibitor) subunit 1Aprovided by RGD
Primary source
RGD:62018
See related
EnsemblRapid:ENSRNOG00000036827 AllianceGenome:RGD:62018
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Located in extracellular space. Orthologous to human PPP1R1A (protein phosphatase 1 regulatory inhibitor subunit 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Muscle (RPKM 356.5), Kidney (RPKM 325.1) and 3 other tissues See more
Orthologs
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Genomic context

See Ppp1r1a in Genome Data Viewer
Location:
7q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136533031..136540687, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134654578..134662236, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (145146480..145154131, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NCK associated protein 1 like Neighboring gene uncharacterized LOC134479586 Neighboring gene phosphodiesterase 1B Neighboring gene glycosylation dependent cell adhesion molecule 1 Neighboring gene uncharacterized LOC102547969

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in glycogen metabolic process  
involved_in intracellular signal transduction  
involved_in signal transduction  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in extracellular space PubMed 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 1A
Names
I-1
IPP-1
PP1 inhibitor 1
protein phosphatase inhibitor 1
NP_073167.1
XP_006242499.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022676.3NP_073167.1  protein phosphatase 1 regulatory subunit 1A

    See identical proteins and their annotated locations for NP_073167.1

    Status: PROVISIONAL

    Source sequence(s)
    AY648296
    UniProtKB/Swiss-Prot
    P19103, Q6DSU5
    UniProtKB/TrEMBL
    A6KD15, A6KD17
    Related
    ENSRNOP00000052146.2, ENSRNOT00000055271.4
    Conserved Domains (1) summary
    pfam05395
    Location:5142
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    136533031..136540687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242437.5XP_006242499.1  protein phosphatase 1 regulatory subunit 1A isoform X1

    UniProtKB/TrEMBL
    A6KD15
    Conserved Domains (1) summary
    pfam05395
    Location:5141
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32
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