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    Il17ra interleukin 17 receptor A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312679, updated on 9-Dec-2024

    Summary

    Official Symbol
    Il17raprovided by RGD
    Official Full Name
    interleukin 17 receptor Aprovided by RGD
    Primary source
    RGD:1306559
    See related
    EnsemblRapid:ENSRNOG00000011153 AllianceGenome:RGD:1306559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Il17r
    Summary
    Predicted to enable interleukin-17 receptor activity and signaling receptor binding activity. Involved in cellular response to cytokine stimulus. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 51. Orthologous to human IL17RA (interleukin 17 receptor A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 301.8), Thymus (RPKM 211.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Il17ra in Genome Data Viewer
    Location:
    4q42
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (155339742..155362382)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (153667534..153690174)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (152995865..153018394)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transfer RNA leucine (anticodon AAG) 13 Neighboring gene coiled-coil domain containing 77 Neighboring gene lysine demethylase 5A Neighboring gene transmembrane protein 121B Neighboring gene haloacid dehalogenase like hydrolase domain containing 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables interleukin-17 receptor activity  
    enables interleukin-17 receptor activity  
    enables signaling receptor binding  
    Process Evidence Code Pubs
    involved_in T-helper 17 type immune response  
    involved_in cellular response to cytokine stimulus PubMed 
    involved_in defense response to fungus  
    involved_in fibroblast activation  
    involved_in granulocyte chemotaxis  
    involved_in interleukin-17-mediated signaling pathway  
    involved_in interleukin-17A-mediated signaling pathway  
    involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production  
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of cytokine production involved in inflammatory response  
    acts_upstream_of_or_within positive regulation of inflammatory response  
    involved_in positive regulation of inflammatory response  
    acts_upstream_of_or_within positive regulation of interleukin-13 production  
    involved_in positive regulation of interleukin-23 production  
    acts_upstream_of_or_within positive regulation of interleukin-5 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in protein catabolic process  
    involved_in response to virus  
    Component Evidence Code Pubs
    located_in plasma membrane  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107883.2NP_001101353.2  interleukin-17 receptor A precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6ILA4, D4A740
      Related
      ENSRNOP00000014885.7, ENSRNOT00000014885.8
      Conserved Domains (3) summary
      pfam08357
      Location:380539
      SEFIR; SEFIR domain
      pfam16556
      Location:48198
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
      pfam16578
      Location:199303
      IL17R_fnIII_D2; Interleukin 17 receptor D

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      155339742..155362382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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