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St6galnac3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29758, updated on 9-Dec-2024

Summary

Official Symbol
St6galnac3provided by RGD
Official Full Name
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3provided by RGD
Primary source
RGD:3677
See related
EnsemblRapid:ENSRNOG00000056894 AllianceGenome:RGD:3677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat7c
Summary
Enables sialyltransferase activity. Predicted to be involved in ceramide metabolic process; glycoprotein metabolic process; and oligosaccharide metabolic process. Predicted to be located in nucleoplasm. Orthologous to human ST6GALNAC3 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 250.7), Brain (RPKM 72.2) and 7 other tissues See more
Orthologs
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Genomic context

See St6galnac3 in Genome Data Viewer
Location:
2q45
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (244789627..245304975, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (242129755..242645120, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (259379653..259918813, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Neighboring gene uncharacterized LOC134485772 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC103691740 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in ganglioside biosynthetic process  
involved_in glycoprotein metabolic process  
involved_in glycosphingolipid metabolic process  
involved_in glycosylceramide metabolic process  
involved_in glycosylceramide metabolic process  
involved_in lipid metabolic process  
involved_in oligosaccharide metabolic process  
involved_in protein glycosylation  
Component Evidence Code Pubs
located_in Golgi membrane  
located_in nucleoplasm  
located_in nucleoplasm  

General protein information

Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Names
((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C
SIAT7-C
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
ST6 GalNAc alpha-2,6-sialyltransferase 3
ST6GalNAc III
ST6GalNAcIII
STY
galNAc alpha-2,6-sialyltransferase III
sialyltransferase 7 ((alpha-N-acetylneuraminyl 23-betagalactosyl-13)-N-acetyl galactosaminide alpha-26-sialyltransferase) C
sialyltransferase 7c
NP_061996.2
XP_038958059.1
XP_038958060.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019123.2NP_061996.2  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A096MK04, A6HWN0, Q6IN13
    Related
    ENSRNOP00000073209.1, ENSRNOT00000082253.3
    Conserved Domains (1) summary
    pfam00777
    Location:77297
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    244789627..245304975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102131.2XP_038958059.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:12232
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_039102132.2XP_038958060.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:77135
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
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