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Myl9 myosin light chain 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296313, updated on 27-Dec-2024

Summary

Official Symbol
Myl9provided by RGD
Official Full Name
myosin light chain 9provided by RGD
Primary source
RGD:1311235
See related
EnsemblRapid:ENSRNOG00000020246 AllianceGenome:RGD:1311235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable myosin heavy chain binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in myofibril assembly; platelet aggregation; and stress fiber assembly. Predicted to be located in Z disc. Predicted to be part of myosin II complex. Predicted to be active in myofibril and stress fiber. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to human MYL9 (myosin light chain 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Uterus (RPKM 1884.6), Heart (RPKM 1193.3) and 7 other tissues See more
Orthologs
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Genomic context

See Myl9 in Genome Data Viewer
Location:
3q42
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (165742020..165748409)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (145281943..145288333)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (152857573..152863961)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486192 Neighboring gene DLG associated protein 4 Neighboring gene uncharacterized LOC103691945 Neighboring gene uncharacterized LOC102551821 Neighboring gene uncharacterized LOC120101767 Neighboring gene TGFB-induced factor homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding  
enables myosin heavy chain binding  
enables myosin heavy chain binding  
enables myosin heavy chain binding  
enables structural constituent of cytoskeleton  
Process Evidence Code Pubs
involved_in myofibril assembly  
involved_in platelet aggregation PubMed 
involved_in stress fiber assembly  
Component Evidence Code Pubs
located_in Z disc  
located_in Z disc  
located_in cell cortex  
is_active_in cytoplasm  
is_active_in myofibril  
part_of myosin II complex  
part_of myosin II complex  
part_of myosin II complex  
is_active_in stress fiber  
located_in stress fiber  
is_active_in stress fiber  
located_in stress fiber  

General protein information

Preferred Names
myosin regulatory light polypeptide 9
Names
myosin regulatory light chain 9
myosin, light chain 9, regulatory
myosin, light polypeptide 9, regulatory

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100885.3NP_001094355.2  myosin regulatory light polypeptide 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q64122
    UniProtKB/TrEMBL
    B0BMS8, F7F3J1
    Conserved Domains (1) summary
    COG5126
    Location:19169
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. NM_001430178.1NP_001417107.1  myosin regulatory light polypeptide 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q64122
    UniProtKB/TrEMBL
    B0BMS8, F7F3J1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    165742020..165748409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235402.4XP_006235464.1  myosin regulatory light polypeptide 9 isoform X1

    Related
    ENSRNOP00000027445.5, ENSRNOT00000027445.9
    Conserved Domains (1) summary
    COG5126
    Location:19169
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
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