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    Mapkapk3 MAPK activated protein kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315994, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mapkapk3provided by RGD
    Official Full Name
    MAPK activated protein kinase 3provided by RGD
    Primary source
    RGD:1304980
    See related
    EnsemblRapid:ENSRNOG00000014832 AllianceGenome:RGD:1304980
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MK-3; MAPKAP-K3
    Summary
    Predicted to enable calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including macropinocytosis; peptidyl-serine phosphorylation; and response to lipopolysaccharide. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK3 (MAPK activated protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 184.3), Heart (RPKM 103.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mapkapk3 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (116808429..116842228, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107929754..107963638, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116012126..116046012, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene dedicator of cyto-kinesis 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene bleomycin hydrolase, pseudogene 1 Neighboring gene ribosomal protein SA, pseudogene 9 Neighboring gene cytokine inducible SH2-containing protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 29
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables calcium-dependent protein serine/threonine kinase activity  
    enables calcium/calmodulin-dependent protein kinase activity  
    enables calmodulin binding  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables mitogen-activated protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in chromatin remodeling  
    involved_in intracellular signal transduction  
    involved_in macropinocytosis  
    involved_in macropinocytosis  
    involved_in peptidyl-serine phosphorylation  
    involved_in response to cytokine  
    involved_in response to cytokine  
    involved_in response to cytokine  
    involved_in response to lipopolysaccharide  
    involved_in response to lipopolysaccharide  
    involved_in toll-like receptor signaling pathway  
    involved_in toll-like receptor signaling pathway  
    involved_in toll-like receptor signaling pathway  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    MAP kinase-activated protein kinase 3
    Names
    MAPKAP kinase 3
    MAPKAPK-3
    mitogen-activated protein kinase-activated protein kinase 3
    NP_001012127.1
    XP_008764753.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012127.1NP_001012127.1  MAP kinase-activated protein kinase 3

      See identical proteins and their annotated locations for NP_001012127.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081974
      UniProtKB/Swiss-Prot
      Q66H84
      UniProtKB/TrEMBL
      A0A8I6AVR4, A6I2W4
      Related
      ENSRNOP00000020065.3, ENSRNOT00000020065.7
      Conserved Domains (1) summary
      cd14172
      Location:41306
      STKc_MAPKAPK3; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      116808429..116842228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766531.4XP_008764753.1  MAP kinase-activated protein kinase 3 isoform X1

      See identical proteins and their annotated locations for XP_008764753.1

      UniProtKB/Swiss-Prot
      Q66H84
      UniProtKB/TrEMBL
      A0A8I6AVR4, A6I2W4
      Conserved Domains (1) summary
      cd14172
      Location:41306
      STKc_MAPKAPK3; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3
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