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Drd5 dopamine receptor D5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25195, updated on 9-Dec-2024

Summary

Official Symbol
Drd5provided by RGD
Official Full Name
dopamine receptor D5provided by RGD
Primary source
RGD:2523
See related
EnsemblRapid:ENSRNOG00000005338 AllianceGenome:RGD:2523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
D1B
Summary
Enables G-protein alpha-subunit binding activity and dopamine neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; negative regulation of protein kinase activity; and visual learning. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in several cellular components, including brush border membrane; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and blepharospasm. Orthologous to human DRD5 (dopamine receptor D5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Drd5 in Genome Data Viewer
Location:
14q21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (76700244..76703344, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (72487950..72491050, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (77220579..77222006, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 1 Neighboring gene uncharacterized LOC134481771 Neighboring gene solute carrier family 2 member 9 Neighboring gene otopetrin 1 Neighboring gene transmembrane protein 128

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 45
Process Evidence Code Pubs
involved_in G protein-coupled dopamine receptor signaling pathway  
involved_in G protein-coupled dopamine receptor signaling pathway PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway  
involved_in adenylate cyclase-activating dopamine receptor signaling pathway  
involved_in adenylate cyclase-activating dopamine receptor signaling pathway PubMed 
involved_in adenylate cyclase-activating dopamine receptor signaling pathway  
involved_in associative learning  
acts_upstream_of_or_within associative learning  
involved_in cellular response to catecholamine stimulus  
involved_in long-term synaptic depression  
acts_upstream_of_or_within long-term synaptic depression  
acts_upstream_of_or_within mating behavior  
involved_in negative regulation of NAD(P)H oxidase activity  
involved_in negative regulation of blood pressure  
acts_upstream_of_or_within negative regulation of blood pressure  
involved_in negative regulation of cell migration PubMed 
involved_in negative regulation of protein kinase activity PubMed 
involved_in norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure  
acts_upstream_of_or_within norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure  
involved_in positive regulation of MAPK cascade  
involved_in reactive oxygen species metabolic process  
involved_in reactive oxygen species metabolic process  
involved_in regulation of female receptivity  
acts_upstream_of_or_within regulation of female receptivity  
involved_in regulation of locomotion  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
involved_in regulation of systemic arterial blood pressure by vasopressin  
acts_upstream_of_or_within regulation of systemic arterial blood pressure by vasopressin  
involved_in response to amphetamine  
acts_upstream_of_or_within response to amphetamine  
involved_in response to cocaine  
acts_upstream_of_or_within response to cocaine  
involved_in sensitization  
acts_upstream_of_or_within sensitization  
involved_in synaptic transmission, dopaminergic  
involved_in transmission of nerve impulse  
acts_upstream_of_or_within transmission of nerve impulse  
involved_in visual learning PubMed 
involved_in wound healing  
acts_upstream_of_or_within wound healing  
Items 1 - 25 of 45
Component Evidence Code Pubs
located_in axon PubMed 
located_in brush border membrane PubMed 
located_in brush border membrane  
located_in brush border membrane  
located_in ciliary membrane  
located_in ciliary membrane  
located_in cilium  
located_in dendrite PubMed 
located_in dendritic spine PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in glutamatergic synapse  
located_in neuronal cell body PubMed 
located_in non-motile cilium  
located_in non-motile cilium  
is_active_in plasma membrane  
located_in plasma membrane  
is_active_in postsynaptic density membrane PubMed 

General protein information

Preferred Names
D(1B) dopamine receptor
Names
d(5) dopamine receptor
dopamine D5 receptor
dopamine receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012768.2NP_036900.2  D(1B) dopamine receptor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    P25115
    UniProtKB/TrEMBL
    A6IJT5, G3V6N6
    Related
    ENSRNOP00000007074.1, ENSRNOT00000007074.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    76700244..76703344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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