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Abca5 ATP binding cassette subfamily A member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286970, updated on 9-Dec-2024

Summary

Official Symbol
Abca5provided by RGD
Official Full Name
ATP binding cassette subfamily A member 5provided by RGD
Primary source
RGD:628661
See related
EnsemblRapid:ENSRNOG00000004378 AllianceGenome:RGD:628661
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in several processes, including cholesterol efflux; cholesterol homeostasis; and regulation of cholesterol transport. Predicted to be located in lysosome. Predicted to be active in late endosome. Orthologous to human ABCA5 (ATP binding cassette subfamily A member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 128.8), Brain (RPKM 80.2) and 9 other tissues See more
Orthologs
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Genomic context

See Abca5 in Genome Data Viewer
Location:
10q32.1
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (95739610..95808633, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (95240159..95309195, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (98573226..98645028, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 9 Neighboring gene ATP binding cassette subfamily A member 6 Neighboring gene mitogen-activated protein kinase kinase 6 Neighboring gene uncharacterized LOC102551705

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ABC-type transporter activity  
enables ATP binding  
enables ATP hydrolysis activity  
enables ATPase-coupled transmembrane transporter activity  
enables lipid transporter activity  
Process Evidence Code Pubs
involved_in cholesterol efflux  
involved_in cholesterol homeostasis  
involved_in cholesterol homeostasis  
involved_in cholesterol metabolic process  
involved_in cholesterol metabolic process  
involved_in high-density lipoprotein particle remodeling  
involved_in lipid transport  
involved_in negative regulation of macrophage derived foam cell differentiation  
involved_in positive regulation of reverse cholesterol transport  
involved_in positive regulation of reverse cholesterol transport  
involved_in regulation of cholesterol efflux  
involved_in regulation of cholesterol efflux  
involved_in sterol transport PubMed 
involved_in transmembrane transport  
Component Evidence Code Pubs
located_in Golgi membrane  
is_active_in late endosome  
located_in late endosome  
located_in late endosome membrane  
located_in lysosomal membrane  
located_in lysosome  
located_in membrane  
located_in plasma membrane  

General protein information

Preferred Names
cholesterol transporter ABCA5
Names
ATP-binding cassette sub-family A member 5
ATP-binding cassette, sub-family A (ABC1), member 5
ATP-binding cassette, subfamily A (ABC1), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173307.1 → NP_775429.1  cholesterol transporter ABCA5

    See identical proteins and their annotated locations for NP_775429.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ426052
    UniProtKB/Swiss-Prot
    Q80Z07, Q8CF82
    UniProtKB/TrEMBL
    A6HKD1
    Related
    ENSRNOP00000005848.4, ENSRNOT00000005848.8
    Conserved Domains (3) summary
    cd03263
    Location:478 → 701
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    COG1131
    Location:1288 → 1615
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    pfam12698
    Location:214 → 416
    ABC2_membrane_3; ABC-2 family transporter protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    95739610..95808633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268503.1 → XP_063124573.1  cholesterol transporter ABCA5 isoform X1

RNA

  1. XR_010055131.1 RNA Sequence

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