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Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65248, updated on 9-Dec-2024

Summary

Official Symbol
Prkaa1provided by RGD
Official Full Name
protein kinase AMP-activated catalytic subunit alpha 1provided by RGD
Primary source
RGD:3387
See related
EnsemblRapid:ENSRNOG00000012799 AllianceGenome:RGD:3387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AMPKalpha1
Summary
Enables AMP-activated protein kinase activity and ATP binding activity. Involved in several processes, including cellular response to ethanol; cold acclimation; and fatty acid homeostasis. Located in several cellular components, including apical plasma membrane; dendrite; and neuronal cell body. Part of nucleotide-activated protein kinase complex. Used to study type 2 diabetes mellitus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; and colon cancer. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 151.7), Kidney (RPKM 114.0) and 9 other tissues See more
Orthologs
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Genomic context

See Prkaa1 in Genome Data Viewer
Location:
2q16
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (55967766..56003450)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (54240298..54275978)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (54857688..54893404)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family, member 6 Neighboring gene small nucleolar RNA, C/D box 72 Neighboring gene ribosomal protein L37 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 5 Neighboring gene uncharacterized LOC120100730 Neighboring gene prostaglandin E receptor 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 39
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity PubMed 
enables AMP-activated protein kinase activity  
enables AMP-activated protein kinase activity PubMed 
enables AMP-activated protein kinase activity  
enables ATP binding PubMed 
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity  
enables chromatin binding  
enables chromatin binding  
enables eukaryotic elongation factor-2 kinase activator activity PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables metal ion binding  
enables protein binding PubMed 
enables protein kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables protein-containing complex binding PubMed 
enables ribosomal protein S6 kinase activity  
enables tau-protein kinase activity  
Items 1 - 25 of 39
Items 1 - 25 of 87
Process Evidence Code Pubs
involved_in CAMKK-AMPK signaling cascade  
involved_in Wnt signaling pathway  
involved_in autophagy  
involved_in cellular response to calcium ion PubMed 
involved_in cellular response to calcium ion  
involved_in cellular response to ethanol PubMed 
involved_in cellular response to glucose starvation  
involved_in cellular response to glucose starvation  
involved_in cellular response to glucose starvation  
involved_in cellular response to glucose stimulus PubMed 
involved_in cellular response to glucose stimulus  
involved_in cellular response to hydrogen peroxide PubMed 
involved_in cellular response to hypoxia PubMed 
involved_in cellular response to nutrient levels  
involved_in cellular response to nutrient levels  
involved_in cellular response to oxidative stress  
acts_upstream_of_or_within cellular response to prostaglandin E stimulus  
involved_in cellular response to stress  
involved_in cellular response to xenobiotic stimulus PubMed 
involved_in cholesterol biosynthetic process  
involved_in chromatin remodeling  
involved_in cold acclimation PubMed 
involved_in energy homeostasis PubMed 
involved_in energy homeostasis  
involved_in fatty acid biosynthetic process  
involved_in fatty acid homeostasis PubMed 
acts_upstream_of_or_within fatty acid oxidation  
involved_in glucose homeostasis  
involved_in glucose homeostasis  
acts_upstream_of_or_within glucose metabolic process  
involved_in lipid biosynthetic process  
involved_in lipid biosynthetic process  
acts_upstream_of_positive_effect lipid droplet disassembly  
acts_upstream_of_positive_effect lipid droplet disassembly  
involved_in motor behavior  
involved_in negative regulation of TOR signaling  
involved_in negative regulation of TOR signaling  
involved_in negative regulation of TOR signaling  
involved_in negative regulation of TORC1 signaling  
involved_in negative regulation of TORC1 signaling  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of gene expression  
involved_in negative regulation of hepatocyte apoptotic process  
involved_in negative regulation of hepatocyte apoptotic process  
involved_in negative regulation of insulin receptor signaling pathway PubMed 
involved_in negative regulation of lipid catabolic process  
involved_in negative regulation of lipid catabolic process  
involved_in negative regulation of translation PubMed 
involved_in negative regulation of tubulin deacetylation  
involved_in neuron cellular homeostasis  
involved_in positive regulation of D-glucose import PubMed 
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of T cell activation  
involved_in positive regulation of T cell mediated immune response to tumor cell  
involved_in positive regulation of adipose tissue development  
involved_in positive regulation of autophagy  
involved_in positive regulation of autophagy  
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of fatty acid oxidation PubMed 
acts_upstream_of_or_within positive regulation of gene expression  
involved_in positive regulation of gluconeogenesis PubMed 
involved_in positive regulation of glycolytic process PubMed 
involved_in positive regulation of mitochondrial transcription  
involved_in positive regulation of peptidyl-lysine acetylation  
involved_in positive regulation of protein localization  
involved_in positive regulation of protein targeting to mitochondrion  
acts_upstream_of_or_within positive regulation of skeletal muscle tissue development  
involved_in protein localization to lipid droplet  
involved_in protein localization to lipid droplet  
involved_in protein phosphorylation PubMed 
involved_in protein phosphorylation PubMed 
involved_in regulation of circadian rhythm  
involved_in regulation of circadian rhythm  
involved_in regulation of microtubule cytoskeleton organization  
acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation  
involved_in regulation of stress granule assembly  
involved_in regulation of vesicle-mediated transport PubMed 
involved_in response to UV  
involved_in response to activity PubMed 
involved_in response to caffeine PubMed 
involved_in response to estrogen PubMed 
involved_in response to gamma radiation  
involved_in response to gamma radiation  
involved_in response to hydrogen peroxide  
involved_in response to xenobiotic stimulus PubMed 
involved_in rhythmic process  
Items 1 - 25 of 87
Items 1 - 20 of 27
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
located_in axon PubMed 
located_in axon  
is_active_in chromatin  
located_in chromatin  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoplasm  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytosol PubMed 
located_in cytosol  
located_in cytosol  
located_in dendrite PubMed 
located_in dendrite  
located_in neuronal cell body PubMed 
located_in neuronal cell body  
located_in nuclear speck  
located_in nuclear speck  
part_of nucleotide-activated protein kinase complex  
part_of nucleotide-activated protein kinase complex PubMed 
part_of nucleotide-activated protein kinase complex  
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus  
located_in nucleus  
part_of protein-containing complex PubMed 
Items 1 - 20 of 27

General protein information

Preferred Names
5'-AMP-activated protein kinase catalytic subunit alpha-1
Names
ACACA kinase
AMPK alpha-1 chain
HMGCR kinase
acetyl-CoA carboxylase kinase
hydroxymethylglutaryl-CoA reductase kinase
protein kinase, AMP-activated, alpha 1 catalytic subunit
tau-protein kinase PRKAA1
NP_062015.2
XP_038959025.1
XP_063138576.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019142.4NP_062015.2  5'-AMP-activated protein kinase catalytic subunit alpha-1

    See identical proteins and their annotated locations for NP_062015.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P54645
    UniProtKB/TrEMBL
    A6KGD8
    Related
    ENSRNOP00000017626.4, ENSRNOT00000017626.7
    Conserved Domains (3) summary
    cd12199
    Location:404557
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:296360
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cd14079
    Location:24279
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    55967766..56003450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103097.2XP_038959025.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GCD0
    Conserved Domains (3) summary
    cd12199
    Location:320473
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:212276
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cl21453
    Location:7195
    PKc_like; Protein Kinases, catalytic domain
  2. XM_063282506.1XP_063138576.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GCD0
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