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Prep prolyl endopeptidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 83471, updated on 9-Dec-2024

Summary

Official Symbol
Prepprovided by RGD
Official Full Name
prolyl endopeptidaseprovided by RGD
Primary source
RGD:620841
See related
EnsemblRapid:ENSRNOG00000051061 AllianceGenome:RGD:620841
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rPop
Summary
Enables endopeptidase activity and peptide binding activity. Involved in protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Biomarker of depressive disorder. Orthologous to human PREP (prolyl endopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Muscle (RPKM 107.1), Kidney (RPKM 96.8) and 9 other tissues See more
Orthologs
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Genomic context

See Prep in Genome Data Viewer
Location:
20q13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (50138588..50235549)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (48556211..48653165)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (50172618..50269992)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555236 Neighboring gene uncharacterized LOC102555144 Neighboring gene uncharacterized LOC134483831 Neighboring gene uncharacterized LOC120098962 Neighboring gene small nucleolar RNA SNORA29 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity PubMed 
enables oligopeptidase activity  
enables peptide binding PubMed 
enables serine-type endopeptidase activity  
Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoplasm  
is_active_in cytosol  
located_in cytosol  
located_in cytosol  
located_in nucleus  
located_in nucleus  

General protein information

Preferred Names
prolyl endopeptidase
Names
PE
post-proline cleaving enzyme
NP_112614.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031324.2NP_112614.2  prolyl endopeptidase

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    O70196
    UniProtKB/TrEMBL
    A0A0G2K1M8, A6K6V5
    Related
    ENSRNOP00000110849.1, ENSRNOT00000160646.1
    Conserved Domains (1) summary
    COG1505
    Location:26704
    PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    50138588..50235549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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