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Atp8a1 ATPase phospholipid transporting 8A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289615, updated on 9-Dec-2024

Summary

Official Symbol
Atp8a1provided by RGD
Official Full Name
ATPase phospholipid transporting 8A1provided by RGD
Primary source
RGD:1309619
See related
EnsemblRapid:ENSRNOG00000034200 AllianceGenome:RGD:1309619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylserine flippase activity. Predicted to be involved in several processes, including learning; regulation of membrane lipid distribution; and synaptic vesicle endocytosis. Is active in synaptic vesicle membrane. Orthologous to human ATP8A1 (ATPase phospholipid transporting 8A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 314.3), Lung (RPKM 276.3) and 9 other tissues See more
Orthologs
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Genomic context

See Atp8a1 in Genome Data Viewer
Location:
14p11
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (40668932..40911465)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (40315013..40557572)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (41972398..42210555)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene glutaredoxin and cysteine rich domain containing 1 Neighboring gene uncharacterized LOC120096602 Neighboring gene uncharacterized LOC134481745 Neighboring gene shisa family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables ATP hydrolysis activity  
enables ATPase-coupled intramembrane lipid transporter activity  
enables magnesium ion binding  
enables metal ion binding  
enables phosphatidylserine flippase activity  
Process Evidence Code Pubs
involved_in aminophospholipid translocation  
involved_in learning  
involved_in phospholipid translocation  
involved_in positive regulation of cell migration  
involved_in positive regulation of phospholipid translocation  
involved_in synaptic vesicle endocytosis  
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in cytoplasmic vesicle  
located_in cytosol  
located_in cytosol  
located_in endoplasmic reticulum  
is_active_in glutamatergic synapse  
located_in intracellular membrane-bounded organelle  
located_in organelle membrane  
part_of phospholipid-translocating ATPase complex  
is_active_in plasma membrane  
located_in plasma membrane  
is_active_in synapse  
is_active_in synaptic vesicle membrane PubMed 
is_active_in synaptic vesicle membrane PubMed 
is_active_in synaptic vesicle membrane  
is_active_in trans-Golgi network  

General protein information

Preferred Names
phospholipid-transporting ATPase IA
Names
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
probable phospholipid-transporting ATPase IA
NP_001413924.1
XP_006251042.1
XP_038948654.1
XP_038948656.1
XP_038948657.1
XP_038948658.1
XP_063128992.1
XP_063128993.1
XP_063128994.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426995.2NP_001413924.1  phospholipid-transporting ATPase IA

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6AVY6, A6JDA0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    40668932..40911465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092730.2XP_038948658.1  phospholipid-transporting ATPase IA isoform X4

    UniProtKB/TrEMBL
    A6JDA0
    Conserved Domains (1) summary
    TIGR01652
    Location:491096
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
  2. XM_063272922.1XP_063128992.1  phospholipid-transporting ATPase IA isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZXX6, A6JDA0
  3. XM_063272923.1XP_063128993.1  phospholipid-transporting ATPase IA isoform X6

    UniProtKB/TrEMBL
    A6JDA0
  4. XM_039092726.2XP_038948654.1  phospholipid-transporting ATPase IA isoform X1

    UniProtKB/TrEMBL
    A6JDA0
    Conserved Domains (1) summary
    TIGR01652
    Location:941131
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
  5. XM_039092729.2XP_038948657.1  phospholipid-transporting ATPase IA isoform X3

    UniProtKB/TrEMBL
    A6JDA0
    Conserved Domains (1) summary
    TIGR01652
    Location:941116
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
  6. XM_039092728.2XP_038948656.1  phospholipid-transporting ATPase IA isoform X2

    UniProtKB/TrEMBL
    A6JDA0
    Conserved Domains (1) summary
    TIGR01652
    Location:941131
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
  7. XM_006250980.4XP_006251042.1  phospholipid-transporting ATPase IA isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZKC1
    Related
    ENSRNOP00000077596.1, ENSRNOT00000099913.2
    Conserved Domains (5) summary
    TIGR01484
    Location:489654
    HAD-SF-IIB; HAD-superfamily hydrolase, subfamily IIB
    TIGR01494
    Location:14716
    ATPase_P-type; ATPase, P-type (transporting), HAD superfamily, subfamily IC
    pfam13246
    Location:322417
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:663915
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:632661
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  8. XM_063272924.1XP_063128994.1  phospholipid-transporting ATPase IA isoform X8

    UniProtKB/TrEMBL
    A0A8I6G2I8
    Related
    ENSRNOP00000039929.6, ENSRNOT00000044017.7
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