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Uroc1 urocanate hydratase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 685999, updated on 9-Dec-2024

Summary

Symbol
Uroc1provided by RGD
Full Name
urocanate hydratase 1provided by RGD
Primary source
RGD:1587777
See related
EnsemblRapid:ENSRNOG00000043404 AllianceGenome:RGD:1587777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable urocanate hydratase activity. Predicted to be involved in L-histidine catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in urocanase deficiency. Orthologous to human UROC1 (urocanate hydratase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward (RPKM 434.3) See more
Orthologs
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Genomic context

See Uroc1 in Genome Data Viewer
Location:
4q34
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (124402119..124433787)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (122844933..122876584)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (122244744..122276357)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486811 Neighboring gene similar to human chromosome 3 open reading frame 22 Neighboring gene carbohydrate sulfotransferase 13 Neighboring gene uncharacterized LOC134486812 Neighboring gene ZXD family zinc finger C Neighboring gene cilia and flagella associated protein 100

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables urocanate hydratase activity  
enables urocanate hydratase activity  
Component Evidence Code Pubs
located_in cytosol  

General protein information

Preferred Names
urocanate hydratase; urocanate hydratase 1
Names
urocanase domain containing 1
urocanate hydratase-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431883.1NP_001418812.1  urocanate hydratase 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IB77, D3ZIC2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    124402119..124433787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001066120.8XP_001066120.2  urocanate hydratase

    Related
    ENSRNOP00000032936.4, ENSRNOT00000038251.7
    Conserved Domains (1) summary
    PRK05414
    Location:74662
    PRK05414; urocanate hydratase; Provisional
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