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Sqstm1 sequestosome 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 113894, updated on 27-Dec-2024

Summary

Official Symbol
Sqstm1provided by RGD
Official Full Name
sequestosome 1provided by RGD
Primary source
RGD:69287
See related
EnsemblRapid:ENSRNOG00000003147 AllianceGenome:RGD:69287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Osi; ZIP; ZIP3
Summary
Enables identical protein binding activity and protein kinase C binding activity. Involved in positive regulation of protein phosphorylation and response to ischemia. Located in Lewy body. Is active in glutamatergic synapse. Biomarker of acute myocardial infarction; glaucoma; and hypertension. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis 3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Liver (RPKM 1406.7), Muscle (RPKM 1246.9) and 9 other tissues See more
Orthologs
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Genomic context

See Sqstm1 in Genome Data Viewer
Location:
10q22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (35026598..35037750, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34525517..34536670, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35704728..35716316, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 9B Neighboring gene uncharacterized LOC120095090 Neighboring gene MRN complex interacting protein Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene uncharacterized LOC134480781 Neighboring gene leukotriene C4 synthase Neighboring gene mastermind-like transcriptional coactivator 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 30
Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding  
enables K63-linked polyubiquitin modification-dependent protein binding  
enables K63-linked polyubiquitin modification-dependent protein binding  
enables SH2 domain binding  
enables SH2 domain binding  
enables enzyme binding  
enables identical protein binding  
enables identical protein binding  
enables ionotropic glutamate receptor binding  
enables molecular condensate scaffold activity  
enables molecular sequestering activity  
enables protein binding  
enables protein kinase C binding  
enables protein kinase C binding  
enables protein kinase C binding  
enables protein kinase C binding  
enables protein kinase binding  
enables protein sequestering activity  
enables protein sequestering activity  
enables protein-containing complex binding PubMed 
enables protein-macromolecule adaptor activity  
enables protein-macromolecule adaptor activity  
enables signaling adaptor activity  
enables signaling receptor activity  
enables ubiquitin binding  
enables ubiquitin binding  
enables ubiquitin protein ligase binding  
enables ubiquitin-modified protein reader activity  
enables ubiquitin-modified protein reader activity  
enables zinc ion binding  
Items 1 - 25 of 30
Items 1 - 25 of 46
Process Evidence Code Pubs
involved_in aggrephagy  
involved_in aggrephagy  
involved_in aggrephagy  
involved_in apoptotic process  
involved_in autophagy  
involved_in autophagy  
involved_in brown fat cell proliferation  
involved_in cell differentiation  
involved_in cellular response to stress  
involved_in endosome organization  
involved_in endosome organization  
involved_in endosome organization  
involved_in energy homeostasis  
involved_in immune system process  
involved_in macroautophagy  
involved_in macroautophagy  
involved_in membraneless organelle assembly  
involved_in mitophagy  
involved_in mitophagy  
involved_in negative regulation of ferroptosis  
involved_in negative regulation of ferroptosis  
involved_in negative regulation of protein ubiquitination  
involved_in negative regulation of protein ubiquitination  
involved_in negative regulation of toll-like receptor 4 signaling pathway  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
involved_in pexophagy  
involved_in pexophagy  
involved_in positive regulation of autophagy  
involved_in positive regulation of long-term synaptic potentiation  
involved_in positive regulation of protein localization to plasma membrane  
involved_in positive regulation of protein phosphorylation PubMed 
involved_in protein catabolic process  
involved_in protein catabolic process  
involved_in protein import into nucleus  
involved_in protein localization to perinuclear region of cytoplasm  
involved_in protein localization to perinuclear region of cytoplasm  
involved_in protein phosphorylation  
involved_in protein targeting to vacuole involved in autophagy  
involved_in protein targeting to vacuole involved in autophagy  
involved_in regulation of canonical NF-kappaB signal transduction  
involved_in regulation of canonical NF-kappaB signal transduction  
involved_in regulation of protein complex stability  
involved_in response to ischemia PubMed 
involved_in response to mitochondrial depolarisation  
involved_in temperature homeostasis  
acts_upstream_of transcription by RNA polymerase II  
Items 1 - 25 of 46
Items 1 - 20 of 29
Component Evidence Code Pubs
located_in Lewy body PubMed 
located_in P-body  
located_in P-body  
located_in PML body  
is_active_in aggresome  
located_in aggresome  
is_active_in amphisome  
located_in amphisome  
located_in autolysosome  
located_in autophagosome  
is_active_in autophagosome  
located_in autophagosome  
located_in autophagosome  
located_in cytoplasm  
is_active_in cytosol  
located_in cytosol  
located_in endoplasmic reticulum  
is_active_in glutamatergic synapse PubMed 
located_in inclusion body  
located_in intracellular membrane-bounded organelle  
is_active_in intracellular membraneless organelle  
is_active_in intracellular membraneless organelle  
located_in late endosome  
located_in mitochondrion  
located_in nucleus  
located_in phagophore assembly site  
located_in sarcomere  
located_in sperm midpiece  
is_active_in synapse PubMed 
Items 1 - 20 of 29

General protein information

Preferred Names
sequestosome-1
Names
PKC-zeta-interacting protein
oxidative stress induced
protein kinase C-zeta-interacting protein
ubiquitin-binding protein p62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393884.1NP_001380813.1  sequestosome-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HE00
    Related
    ENSRNOP00000004308.8, ENSRNOT00000004308.8
    Conserved Domains (3) summary
    cd06402
    Location:4100
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd02340
    Location:123163
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    pfam16577
    Location:351412
    UBA_5; UBA domain
  2. NM_001393885.1NP_001380814.1  sequestosome-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HE02
    Conserved Domains (3) summary
    cd06402
    Location:4100
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd02340
    Location:123163
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cl21463
    Location:350401
    UBA_like_SF; UBA domain-like superfamily
  3. NM_001393886.1NP_001380815.1  sequestosome-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HE02
    Conserved Domains (3) summary
    cd06402
    Location:4100
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd02340
    Location:123163
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cl21463
    Location:323374
    UBA_like_SF; UBA domain-like superfamily
  4. NM_175843.5NP_787037.2  sequestosome-1 isoform 1

    See identical proteins and their annotated locations for NP_787037.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    O08623, Q8CH59
    UniProtKB/TrEMBL
    A6HE00
    Related
    ENSRNOP00000056021.4, ENSRNOT00000059255.7
    Conserved Domains (3) summary
    cd06402
    Location:4100
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd02340
    Location:123163
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    pfam16577
    Location:378439
    UBA_5; UBA domain
  5. NM_181550.2NP_853528.2  sequestosome-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HE03
    Conserved Domains (2) summary
    cd06402
    Location:4100
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd02340
    Location:123163
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    35026598..35037750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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