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Crispld2 cysteine-rich secretory protein LCCL domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171547, updated on 9-Dec-2024

Summary

Official Symbol
Crispld2provided by RGD
Official Full Name
cysteine-rich secretory protein LCCL domain containing 2provided by RGD
Primary source
RGD:620860
See related
EnsemblRapid:ENSRNOG00000016752 AllianceGenome:RGD:620860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lgl1; Lcrisp2
Summary
Predicted to enable heparin binding activity. Involved in lung development. Predicted to be located in extracellular matrix and transport vesicle. Predicted to be active in extracellular space. Orthologous to human CRISPLD2 (cysteine rich secretory protein LCCL domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 132.9), Uterus (RPKM 130.1) and 8 other tissues See more
Orthologs
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Genomic context

See Crispld2 in Genome Data Viewer
Location:
19q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (64961764..65020099)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (48053153..48111485)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (52647038..52705118)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene kelch-like family member 36 Neighboring gene ubiquitin specific peptidase 10 Neighboring gene RIKEN cDNA 6430548M08 gene like Neighboring gene zinc finger DHHC-type palmitoyltransferase 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycosaminoglycan binding  
enables glycosaminoglycan binding  
enables heparin binding  
Component Evidence Code Pubs
located_in extracellular matrix  
is_active_in extracellular space  
located_in transport vesicle  
located_in transport vesicle  

General protein information

Preferred Names
cysteine-rich secretory protein LCCL domain-containing 2
Names
late gestation lung protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138518.2NP_612527.2  cysteine-rich secretory protein LCCL domain-containing 2 precursor

    See identical proteins and their annotated locations for NP_612527.2

    Status: VALIDATED

    Source sequence(s)
    CA509993, CB732240, CK367026, CK600175, JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A0G2JUW3, A6IZL4
    Conserved Domains (3) summary
    smart00603
    Location:286370
    LCCL; LCCL domain
    cd05380
    Location:56201
    SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...
    pfam03815
    Location:389487
    LCCL; LCCL domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    64961764..65020099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255708.5XP_006255770.1  cysteine-rich secretory protein LCCL domain-containing 2 isoform X1

    See identical proteins and their annotated locations for XP_006255770.1

    UniProtKB/TrEMBL
    A0A0G2JUW3, A6IZL4
    Related
    ENSRNOP00000069254.3, ENSRNOT00000087857.3
    Conserved Domains (3) summary
    smart00603
    Location:286370
    LCCL; LCCL domain
    cd05380
    Location:56201
    SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...
    pfam03815
    Location:389487
    LCCL; LCCL domain
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