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    Smarce1 SWI/SNF related BAF chromatin remodeling complex subunit E1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303518, updated on 27-Dec-2024

    Summary

    Official Symbol
    Smarce1provided by RGD
    Official Full Name
    SWI/SNF related BAF chromatin remodeling complex subunit E1provided by RGD
    Primary source
    RGD:1304726
    See related
    EnsemblRapid:ENSRNOG00000010676 AllianceGenome:RGD:1304726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BAF57; RGD1304726
    Summary
    Predicted to enable N-acetyltransferase activity; RNA binding activity; and nuclear receptor binding activity. Involved in negative regulation of DNA-templated transcription and spermatid development. Predicted to be located in nucleoplasm. Predicted to be part of SWI/SNF complex; nBAF complex; and npBAF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 5; familial meningioma; and meningioma. Orthologous to human SMARCE1 (SWI/SNF related BAF chromatin remodeling complex subunit E1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 292.1), Lung (RPKM 237.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Smarce1 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84655468..84678259, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (84159270..84180547, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (87116827..87138890, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon AGA) 39 Neighboring gene uncharacterized LOC120095183 Neighboring gene C-C motif chemokine receptor 7 Neighboring gene keratin 222 Neighboring gene uncharacterized LOC134480870 Neighboring gene uncharacterized LOC134480871

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables N-acetyltransferase activity  
    enables RNA binding  
    enables RNA binding  
    enables nuclear receptor binding  
    enables nuclear receptor binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF complex  
    part_of SWI/SNF complex  
    part_of SWI/SNF complex  
    part_of nBAF complex  
    part_of nBAF complex  
    part_of npBAF complex  
    part_of npBAF complex  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
    Names
    BRG1-associated factor 57
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024993.2 → NP_001020164.1  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform 2

      See identical proteins and their annotated locations for NP_001020164.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      C0IMX4, C0IMX5, C0IMX6, Q56A18, Q5BJV2
      UniProtKB/TrEMBL
      E9PU44
      Related
      ENSRNOP00000014230.7, ENSRNOT00000014230.9
      Conserved Domains (1) summary
      cd01390
      Location:35 → 96
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
    2. NM_001399629.1 → NP_001386558.1  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HIW9, E9PU44
      Related
      ENSRNOP00000074941.3, ENSRNOT00000083233.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      84655468..84678259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086083.2 → XP_038942011.1  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X2

      UniProtKB/TrEMBL
      A6HIX0, E9PU44
      Conserved Domains (2) summary
      PTZ00121
      Location:180 → 302
      PTZ00121; MAEBL; Provisional
      cd01390
      Location:2 → 61
      HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    2. XM_039086085.2 → XP_038942013.1  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1

      UniProtKB/TrEMBL
      E9PU44
      Conserved Domains (2) summary
      PTZ00121
      Location:127 → 393
      PTZ00121; MAEBL; Provisional
      cd01390
      Location:52 → 113
      HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    3. XM_039086082.2 → XP_038942010.1  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X2

      UniProtKB/TrEMBL
      A6HIX0, E9PU44
      Conserved Domains (2) summary
      PTZ00121
      Location:180 → 302
      PTZ00121; MAEBL; Provisional
      cd01390
      Location:2 → 61
      HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    4. XM_039086084.2 → XP_038942012.1  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X2

      UniProtKB/TrEMBL
      A6HIX0, E9PU44
      Conserved Domains (2) summary
      PTZ00121
      Location:180 → 302
      PTZ00121; MAEBL; Provisional
      cd01390
      Location:2 → 61
      HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
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