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    Pard3 par-3 family cell polarity regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81918, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pard3provided by RGD
    Official Full Name
    par-3 family cell polarity regulatorprovided by RGD
    Primary source
    RGD:620374
    See related
    EnsemblRapid:ENSRNOG00000032437 AllianceGenome:RGD:620374
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Par3
    Summary
    Enables identical protein binding activity; phosphatidylinositol phosphate binding activity; and protein phosphatase binding activity. Involved in several processes, including bicellular tight junction assembly; establishment of epithelial cell polarity; and protein targeting to membrane. Located in axonal growth cone; cell-cell junction; and neuronal cell body. Part of protein-containing complex. Orthologous to human PARD3 (par-3 family cell polarity regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 82.9), Kidney (RPKM 67.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pard3 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (71977420..72527273)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (55080282..55630111)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (60017746..60580628)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene high-mobility group box 1, pseudogene 33 Neighboring gene gamma-aminobutyric acid receptor associated protein like 4 Neighboring gene ribosomal protein L28, pseudogene 7 Neighboring gene uncharacterized LOC103694361 Neighboring gene uncharacterized LOC134483412

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within apical constriction  
    involved_in bicellular tight junction assembly PubMed 
    involved_in cell adhesion  
    involved_in cell division  
    acts_upstream_of_or_within centrosome localization  
    involved_in establishment of cell polarity  
    involved_in establishment of centrosome localization  
    involved_in establishment of epithelial cell polarity PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity PubMed 
    involved_in microtubule cytoskeleton organization  
    acts_upstream_of_or_within microtubule cytoskeleton organization  
    involved_in myelination in peripheral nervous system  
    involved_in myelination in peripheral nervous system  
    involved_in negative regulation of peptidyl-threonine phosphorylation  
    involved_in negative regulation of peptidyl-threonine phosphorylation  
    involved_in positive regulation of myelination  
    involved_in positive regulation of myelination  
    involved_in positive regulation of receptor internalization  
    involved_in protein localization  
    involved_in protein targeting to membrane PubMed 
    acts_upstream_of_or_within regulation of actin filament-based process  
    involved_in regulation of cellular localization PubMed 
    acts_upstream_of_or_within wound healing, spreading of cells  
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    part_of PAR polarity complex  
    located_in Schmidt-Lanterman incisure  
    is_active_in adherens junction  
    located_in adherens junction  
    is_active_in apical junction complex  
    located_in apical junction complex  
    is_active_in apical plasma membrane  
    located_in axonal growth cone PubMed 
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    is_active_in cell cortex  
    located_in cell junction  
    located_in cell-cell junction PubMed 
    located_in cell-cell junction  
    located_in cytoplasm  
    located_in endomembrane system  
    located_in internode region of axon  
    located_in internode region of axon  
    located_in lateral loop  
    located_in neuronal cell body PubMed 
    located_in plasma membrane  
    part_of protein-containing complex PubMed 
    located_in spindle  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    partitioning defective 3 homolog
    Names
    ASBP
    ASIP
    PARD-3
    atypical PKC isotype-specific-interacting protein
    atypical PKC-specific binding protein
    par-3 (partitioning defective 3) homolog
    three-PDZ containing protein similar to C. elegans PAR3 (partitioning defect)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431379.1NP_001418308.1  partitioning defective 3 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6AK77
    2. NM_001431380.1NP_001418309.1  partitioning defective 3 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6AK77
    3. NM_001431381.1NP_001418310.1  partitioning defective 3 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5ZNZ7
    4. NM_001431382.1NP_001418311.1  partitioning defective 3 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6A9A7, A0A8I6AK77
    5. NM_001431383.1NP_001418312.1  partitioning defective 3 homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5ZNZ7
    6. NM_001431384.1NP_001418313.1  partitioning defective 3 homolog isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5ZN95
    7. NM_001431385.1NP_001418314.1  partitioning defective 3 homolog isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5ZN95
    8. NM_001431387.1NP_001418316.1  partitioning defective 3 homolog isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
    9. NM_001431389.1NP_001418318.1  partitioning defective 3 homolog isoform 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6GMQ2
    10. NM_031235.3NP_112514.1  partitioning defective 3 homolog isoform 1

      See identical proteins and their annotated locations for NP_112514.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q9Z340
      UniProtKB/TrEMBL
      A0A8I6AK77, A6KJ58
      Related
      ENSRNOP00000075058.1, ENSRNOT00000078559.3
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      71977420..72527273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601371.3XP_017456860.2  partitioning defective 3 homolog isoform X19

      Related
      ENSRNOP00000097873.1, ENSRNOT00000105322.2
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:283
      DUF3534; N-terminal of Par3 and HAL proteins
    2. XM_006255836.2XP_006255898.1  partitioning defective 3 homolog isoform X15

      Related
      ENSRNOP00000079670.2, ENSRNOT00000109223.2
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    3. XM_017601370.3XP_017456859.2  partitioning defective 3 homolog isoform X18

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:283
      DUF3534; N-terminal of Par3 and HAL proteins
    4. XM_006255828.2XP_006255890.1  partitioning defective 3 homolog isoform X2

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    5. XM_039098024.2XP_038953952.1  partitioning defective 3 homolog isoform X4

      Related
      ENSRNOP00000092087.2, ENSRNOT00000111522.2
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:283
      DUF3534; N-terminal of Par3 and HAL proteins
    6. XM_017601367.3XP_017456856.2  partitioning defective 3 homolog isoform X8

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:283
      DUF3534; N-terminal of Par3 and HAL proteins
    7. XM_006255833.2XP_006255895.1  partitioning defective 3 homolog isoform X10

      Related
      ENSRNOP00000079662.1, ENSRNOT00000095548.2
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    8. XM_006255837.2XP_006255899.1  partitioning defective 3 homolog isoform X17

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    9. XM_039098022.2XP_038953950.1  partitioning defective 3 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6AK77
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:283
      DUF3534; N-terminal of Par3 and HAL proteins
    10. XM_063278311.1XP_063134381.1  partitioning defective 3 homolog isoform X5

      UniProtKB/TrEMBL
      A0A8I6AK77
    11. XM_039098026.2XP_038953954.1  partitioning defective 3 homolog isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZNZ7
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:283
      DUF3534; N-terminal of Par3 and HAL proteins
    12. XM_006255830.2XP_006255892.1  partitioning defective 3 homolog isoform X6

      UniProtKB/TrEMBL
      A0A8I6AGY4, A0A8I6AK77
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    13. XM_039098023.2XP_038953951.1  partitioning defective 3 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6AK77
      Related
      ENSRNOP00000048964.5, ENSRNOT00000042623.6
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:283
      DUF3534; N-terminal of Par3 and HAL proteins
    14. XM_039098025.2XP_038953953.1  partitioning defective 3 homolog isoform X7

      UniProtKB/TrEMBL
      A0A8I6AK77
      Conserved Domains (2) summary
      cd00992
      Location:437516
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:283
      DUF3534; N-terminal of Par3 and HAL proteins
    15. XM_063278312.1XP_063134382.1  partitioning defective 3 homolog isoform X9

      Related
      ENSRNOP00000089028.2, ENSRNOT00000104177.2
    16. XM_017601369.2XP_017456858.2  partitioning defective 3 homolog isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZN95
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:283
      DUF3534; N-terminal of Par3 and HAL proteins
    17. XM_063278313.1XP_063134383.1  partitioning defective 3 homolog isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZN95
    18. XM_039098027.2XP_038953955.1  partitioning defective 3 homolog isoform X13

      UniProtKB/TrEMBL
      A0A8I6AK77
      Conserved Domains (1) summary
      cd00992
      Location:175254
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    19. XM_017601368.3XP_017456857.1  partitioning defective 3 homolog isoform X12

      UniProtKB/TrEMBL
      A0A8I6AK77
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