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Rgs2 regulator of G-protein signaling 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84583, updated on 9-Dec-2024

Summary

Official Symbol
Rgs2provided by RGD
Official Full Name
regulator of G-protein signaling 2provided by RGD
Primary source
RGD:621665
See related
EnsemblRapid:ENSRNOG00000003687 AllianceGenome:RGD:621665
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables beta-tubulin binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of glycine import across plasma membrane; and response to amphetamine. Located in cytoplasmic side of plasma membrane. Biomarker of bladder disease (multiple); glomerulosclerosis; hypertension; liver cirrhosis; and opioid abuse. Orthologous to human RGS2 (regulator of G protein signaling 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 281.5), Brain (RPKM 239.4) and 9 other tissues See more
Orthologs
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Genomic context

See Rgs2 in Genome Data Viewer
Location:
13q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (58350063..58352666, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (55799749..55802354, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (60846458..60849061, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551374 Neighboring gene uncharacterized LOC120096269 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134481507

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein alpha-subunit binding  
enables GTPase activator activity  
enables GTPase activator activity  
enables adenylate cyclase inhibitor activity  
enables beta-tubulin binding PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation  
involved_in maternal process involved in female pregnancy PubMed 
involved_in negative regulation of G protein-coupled receptor signaling pathway PubMed 
involved_in negative regulation of G protein-coupled receptor signaling pathway PubMed 
involved_in negative regulation of G protein-coupled receptor signaling pathway  
involved_in negative regulation of MAP kinase activity  
involved_in negative regulation of cardiac muscle hypertrophy  
involved_in negative regulation of cell growth involved in cardiac muscle cell development PubMed 
involved_in negative regulation of glycine import across plasma membrane PubMed 
involved_in negative regulation of phospholipase activity  
involved_in negative regulation of signal transduction  
involved_in negative regulation of translation PubMed 
involved_in positive regulation of cardiac muscle contraction  
involved_in positive regulation of neuron projection development PubMed 
involved_in regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway  
involved_in relaxation of cardiac muscle  
involved_in relaxation of vascular associated smooth muscle  
involved_in response to amphetamine PubMed 
involved_in response to ethanol PubMed 
involved_in spermatogenesis  
Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in cytoplasmic side of plasma membrane PubMed 
located_in cytoplasmic side of plasma membrane  
located_in cytosol  
located_in membrane  
located_in nucleolus  
located_in nucleus  
located_in nucleus  
located_in nucleus  
located_in plasma membrane  

General protein information

Preferred Names
regulator of G-protein signaling 2
Names
regulator of G-protein signaling protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053453.2NP_445905.1  regulator of G-protein signaling 2

    See identical proteins and their annotated locations for NP_445905.1

    Status: PROVISIONAL

    Source sequence(s)
    AF321837
    UniProtKB/Swiss-Prot
    Q9JHX0
    UniProtKB/TrEMBL
    A6ICP7
    Related
    ENSRNOP00000005156.3, ENSRNOT00000005156.8
    Conserved Domains (1) summary
    cd08709
    Location:84197
    RGS_RGS2; Regulator of G protein signaling (RGS) domain found in the RGS2 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    58350063..58352666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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