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Map1b microtubule-associated protein 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 29456, updated on 27-Dec-2024

Summary

Official Symbol
Map1bprovided by RGD
Official Full Name
microtubule-associated protein 1Bprovided by RGD
Primary source
RGD:3043
See related
EnsemblRapid:ENSRNOG00000017428 AllianceGenome:RGD:3043
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mtap1b
Summary
Enables actin binding activity; microtubule binding activity; and phospholipid binding activity. Involved in several processes, including nervous system development; positive regulation of cell differentiation; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including axon; dendrite; and perikaryon. Part of microtubule associated complex. Biomarker of hypothyroidism and visual epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 83 and periventricular nodular heterotopia. Orthologous to human MAP1B (microtubule associated protein 1B). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 1000.6), Heart (RPKM 118.4) and 4 other tissues See more
Orthologs
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Genomic context

See Map1b in Genome Data Viewer
Location:
2q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (32551423..32644471, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (30817261..30910458, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (29675391..29768750, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene pentatricopeptide repeat domain 2 Neighboring gene mitochondrial ribosomal protein S27 Neighboring gene uncharacterized LOC102553545 Neighboring gene uncharacterized LOC134485714

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding  
enables actin binding PubMed 
enables microtubule binding  
enables microtubule binding PubMed 
enables microtubule binding  
enables microtubule binding PubMed 
enables phospholipid binding PubMed 
enables protein binding PubMed 
enables protein-containing complex binding PubMed 
Items 1 - 25 of 38
Process Evidence Code Pubs
acts_upstream_of_or_within axon extension  
involved_in axonogenesis  
acts_upstream_of_or_within axonogenesis  
involved_in cellular response to growth factor stimulus PubMed 
involved_in cellular response to peptide hormone stimulus PubMed 
involved_in dendrite development  
acts_upstream_of_or_within dendrite development  
involved_in developmental maturation PubMed 
acts_upstream_of_or_within establishment of monopolar cell polarity  
involved_in induction of synaptic plasticity by chemical substance PubMed 
acts_upstream_of intracellular transport  
involved_in microtubule bundle formation PubMed 
acts_upstream_of_or_within microtubule bundle formation  
involved_in microtubule cytoskeleton organization  
involved_in microtubule cytoskeleton organization  
acts_upstream_of_or_within mitochondrion transport along microtubule  
acts_upstream_of_or_within negative regulation of intracellular transport  
involved_in negative regulation of microtubule depolymerization PubMed 
involved_in nervous system development PubMed 
involved_in neuron development PubMed 
involved_in neuron projection development  
involved_in neuron projection development  
acts_upstream_of_or_within odontoblast differentiation  
involved_in peripheral nervous system axon regeneration PubMed 
involved_in positive regulation of axon extension PubMed 
involved_in positive regulation of microtubule polymerization PubMed 
involved_in positive regulation of neuron differentiation PubMed 
involved_in regulation of microtubule depolymerization  
involved_in regulation of postsynapse assembly  
involved_in response to axon injury PubMed 
involved_in response to carbohydrate PubMed 
involved_in response to estradiol PubMed 
involved_in response to insecticide PubMed 
involved_in response to mechanical stimulus PubMed 
involved_in response to nutrient levels PubMed 
involved_in response to vitamin A PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in synapse assembly PubMed 
Items 1 - 25 of 38
Items 1 - 20 of 31
Component Evidence Code Pubs
located_in apical dendrite PubMed 
located_in axon PubMed 
located_in basal dendrite PubMed 
is_active_in cytosol  
located_in cytosol  
is_active_in dendrite  
located_in dendrite PubMed 
located_in dendrite  
located_in dendrite  
located_in dendritic spine  
is_active_in glutamatergic synapse  
located_in growth cone PubMed 
located_in hippocampal mossy fiber PubMed 
is_active_in microtubule  
located_in microtubule PubMed 
located_in microtubule  
part_of microtubule associated complex  
part_of microtubule associated complex PubMed 
is_active_in neuronal cell body  
located_in neuronal cell body PubMed 
located_in neuronal cell body  
located_in neuronal cell body  
located_in perikaryon PubMed 
located_in perinuclear region of cytoplasm PubMed 
located_in photoreceptor outer segment  
located_in plasma membrane  
is_active_in postsynapse  
located_in postsynaptic density  
located_in somatodendritic compartment PubMed 
is_active_in synapse  
located_in varicosity PubMed 
Items 1 - 20 of 31

General protein information

Preferred Names
microtubule-associated protein 1B
Names
MAP-1B
neuraxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019217.1NP_062090.1  microtubule-associated protein 1B

    Status: PROVISIONAL

    Source sequence(s)
    AA925503, BF286433, BG378086, BG665276, CA503854, CA510735, CA510940, CB576609, CB579120, CB580055, CB583564, CB584802, CB610210, CB810012, CF977184, CO393350, X60370
    UniProtKB/Swiss-Prot
    B0BNK3, F1LRL9, P15205, Q62958, Q9ER21, Q9QW92
    Related
    ENSRNOP00000023460.6, ENSRNOT00000023460.7
    Conserved Domains (3) summary
    PTZ00121
    Location:5311158
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:20952348
    PHA03247; large tegument protein UL36; Provisional
    pfam05109
    Location:15431875
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    32551423..32644471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101889.2XP_038957817.1  microtubule-associated protein 1B isoform X1

    UniProtKB/Swiss-Prot
    B0BNK3, F1LRL9, P15205, Q62958, Q9ER21, Q9QW92
    UniProtKB/TrEMBL
    A6I569
    Conserved Domains (3) summary
    PTZ00121
    Location:4051032
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:19692222
    PHA03247; large tegument protein UL36; Provisional
    pfam05109
    Location:14171749
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
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