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Dctn2 dynactin subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299850, updated on 9-Dec-2024

Summary

Official Symbol
Dctn2provided by RGD
Official Full Name
dynactin subunit 2provided by RGD
Primary source
RGD:1303182
See related
EnsemblRapid:ENSRNOG00000025481 AllianceGenome:RGD:1303182
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; protein kinase binding activity; and spectrin binding activity. Predicted to be involved in mitotic metaphase chromosome alignment and mitotic spindle organization. Predicted to act upstream of or within melanosome transport and protein localization to centrosome. Located in centrosome and kinetochore. Part of dynactin complex. Biomarker of synucleinopathy. Orthologous to human DCTN2 (dynactin subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 539.9), Lung (RPKM 406.3) and 9 other tissues See more
Orthologs
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Genomic context

See Dctn2 in Genome Data Viewer
Location:
7q22
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64977338..64992875)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63092061..63107560)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70555953..70571433)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 gamma Neighboring gene kinesin family member 5A Neighboring gene DDIT3 upstream open reading frame protein Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene DNA-damage inducible transcript 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC93976

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding  
enables identical protein binding  
enables protein kinase binding  
enables protein kinase binding  
enables spectrin binding  
enables spectrin binding  
Process Evidence Code Pubs
involved_in melanosome transport  
acts_upstream_of_or_within melanosome transport  
involved_in microtubule-based process  
involved_in mitotic metaphase chromosome alignment  
involved_in mitotic metaphase chromosome alignment  
involved_in mitotic spindle organization  
involved_in mitotic spindle organization  
involved_in mitotic spindle organization  
involved_in protein localization to centrosome  
acts_upstream_of_or_within protein localization to centrosome  
Items 1 - 20 of 23
Component Evidence Code Pubs
is_active_in centrosome  
located_in centrosome PubMed 
located_in centrosome  
located_in centrosome  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
part_of dynactin complex  
part_of dynactin complex PubMed 
part_of dynactin complex  
part_of dynactin complex  
part_of dynein complex  
located_in growth cone  
located_in growth cone  
located_in kinetochore PubMed 
located_in kinetochore  
located_in kinetochore  
located_in membrane  
located_in microtubule  
located_in vesicle  
located_in vesicle  
located_in vesicle  
Items 1 - 20 of 23

General protein information

Preferred Names
dynactin subunit 2
Names
dynactin 2 (p50)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004239.1 → NP_001004239.1  dynactin subunit 2

    See identical proteins and their annotated locations for NP_001004239.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079042
    UniProtKB/Swiss-Prot
    Q6AYH5
    UniProtKB/TrEMBL
    A0A0G2JUC7, A6HQT8
    Related
    ENSRNOP00000008120.5, ENSRNOT00000008120.6
    Conserved Domains (1) summary
    pfam04912
    Location:16 → 400
    Dynamitin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    64977338..64992875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078753.2 → XP_038934681.1  dynactin subunit 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUC7
    Related
    ENSRNOP00000099441.1, ENSRNOT00000152569.1
    Conserved Domains (1) summary
    pfam04912
    Location:16 → 374
    Dynamitin
  2. XM_039078754.2 → XP_038934682.1  dynactin subunit 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JUC7
    Related
    ENSRNOP00000112642.1, ENSRNOT00000145831.1
    Conserved Domains (1) summary
    pfam04912
    Location:13 → 377
    Dynamitin
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