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Cp ceruloplasmin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24268, updated on 9-Dec-2024

Summary

Official Symbol
Cpprovided by RGD
Official Full Name
ceruloplasminprovided by RGD
Primary source
RGD:2387
See related
EnsemblRapid:ENSRNOG00000011913 AllianceGenome:RGD:2387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CERP
Summary
Enables copper ion binding activity. Involved in several processes, including female pregnancy; mammary gland development; and response to copper ion. Located in cell surface and extracellular space. Used to study brain edema. Biomarker of Wilson disease; brain ischemia; heart disease; and hyperthyroidism. Human ortholog(s) of this gene implicated in aceruloplasminemia; epilepsy; and hemosiderosis. Orthologous to human CP (ceruloplasmin). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Liver (RPKM 6726.9), Spleen (RPKM 532.4) and 2 other tissues See more
Orthologs
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Genomic context

Location:
2q24
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (104368336..104427119)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (102439433..102498075)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (104744249..104803034)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial pseudogene Neighboring gene ribosome biogenesis regulator 1 homolog, pseudogene 9 Neighboring gene HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Neighboring gene uncharacterized LOC134485607 Neighboring gene helicase-like transcription factor

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables copper ion binding PubMed 
enables copper ion binding  
enables copper ion binding  
enables ferroxidase activity  
enables ferroxidase activity  
enables glutathione peroxidase activity  
enables glutathione peroxidase activity  
enables oxidoreductase activity  
enables oxidoreductase activity  
enables oxidoreductase activity, acting on metal ions, oxygen as acceptor  
enables oxidoreductase activity, acting on metal ions, oxygen as acceptor  
enables phospholipid-hydroperoxide glutathione peroxidase activity  
enables phospholipid-hydroperoxide glutathione peroxidase activity  
enables protein-folding chaperone binding  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification  
involved_in female pregnancy PubMed 
involved_in intracellular copper ion homeostasis  
involved_in intracellular copper ion homeostasis  
involved_in intracellular iron ion homeostasis  
involved_in intracellular iron ion homeostasis  
involved_in intracellular iron ion homeostasis PubMed 
involved_in iron ion transport  
involved_in lactation PubMed 
involved_in liver development PubMed 
involved_in lung development PubMed 
involved_in mammary gland involution PubMed 
involved_in plasma membrane copper ion transport PubMed 
involved_in response to copper ion PubMed 
involved_in response to nutrient PubMed 
Component Evidence Code Pubs
located_in cell surface PubMed 
located_in extracellular region  
located_in extracellular space PubMed 
located_in extracellular space  
is_active_in plasma membrane  

General protein information

Preferred Names
ceruloplasmin
Names
bilitranslocase
ceruloplasmin (ferroxidase)
cuproxidase ceruloplasmin
ferroxidase ceruloplasmin
glutathione peroxidase ceruloplasmin
glutathione-dependent peroxiredoxin ceruloplasmin
NP_001257890.1
NP_036664.2
XP_063137357.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270961.1 → NP_001257890.1  ceruloplasmin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001257890.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and contains two alternate 3' exons compared to variant 1. The resulting protein (isoform 2), which is longer and has a distinct C-terminus compared to isoform 1, is a glycosylphosphatidylinositol-anchored form.
    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6A708, A6IHC3, Q9JL97
    Related
    ENSRNOP00000089330.1, ENSRNOT00000119964.2
    Conserved Domains (5) summary
    cd04225
    Location:726 → 896
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11012
    Location:907 → 1051
    CuRO_6_ceruloplasmin; The sixth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213 → 353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:569 → 712
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:369 → 566
    Cupredoxin; Cupredoxin superfamily
  2. NM_012532.2 → NP_036664.2  ceruloplasmin isoform 1 precursor

    See identical proteins and their annotated locations for NP_036664.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes a secreted protein (isoform 1).
    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P13635, Q64719
    UniProtKB/TrEMBL
    A6IHC4, G3V7K3
    Related
    ENSRNOP00000016083.4, ENSRNOT00000016083.7
    Conserved Domains (5) summary
    cd04225
    Location:726 → 896
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11012
    Location:907 → 1051
    CuRO_6_ceruloplasmin; The sixth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213 → 353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:569 → 712
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:369 → 566
    Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    104368336..104427119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281287.1 → XP_063137357.1  ceruloplasmin isoform X1

    UniProtKB/TrEMBL
    A0A8I6A708, A6IHC3, Q9JL97

RNA

  1. XR_590972.4 RNA Sequence

    Related
    ENSRNOT00000082627.3
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