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Nkx6-2 NK6 homeobox 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309095, updated on 27-Dec-2024

Summary

Official Symbol
Nkx6-2provided by RGD
Official Full Name
NK6 homeobox 2provided by RGD
Primary source
RGD:1307280
See related
EnsemblRapid:ENSRNOG00000017748 AllianceGenome:RGD:1307280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; regulation of DNA-templated transcription; and regulation of myelination. Predicted to act upstream of or within several processes, including central nervous system myelination; pancreatic A cell differentiation; and regulation of oligodendrocyte differentiation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in spastic ataxia 8. Orthologous to human NKX6-2 (NK6 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 61.6) and Adrenal (RPKM 2.7) See more
Orthologs
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Genomic context

See Nkx6-2 in Genome Data Viewer
Location:
1q41
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (203811582..203813122, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194380149..194383533, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (211922389..211923929, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485196 Neighboring gene uncharacterized LOC134485194 Neighboring gene inositol polyphosphate-5-phosphatase A Neighboring gene cilia and flagella associated protein 46 Neighboring gene uncharacterized LOC134485197

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell differentiation  
acts_upstream_of cell fate commitment  
acts_upstream_of_or_within central nervous system myelination  
acts_upstream_of_or_within endocrine pancreas development  
involved_in negative regulation of DNA-templated transcription  
acts_upstream_of_or_within negative regulation of cell fate commitment  
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within neuromuscular process controlling balance  
acts_upstream_of neuron fate commitment  
acts_upstream_of oligodendrocyte differentiation  
acts_upstream_of_or_within oligodendrocyte differentiation  
acts_upstream_of_or_within pancreatic A cell differentiation  
acts_upstream_of_or_within positive regulation of cell fate commitment  
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation  
involved_in regulation of myelination  
involved_in regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
Component Evidence Code Pubs
is_active_in nucleus  
located_in nucleus  

General protein information

Preferred Names
homeobox protein Nkx-6.2
Names
NK6 transcription factor related, locus 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107558.2NP_001101028.1  homeobox protein Nkx-6.2

    See identical proteins and their annotated locations for NP_001101028.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HXC1, D3ZZX2
    Related
    ENSRNOP00000051771.2, ENSRNOT00000054887.5
    Conserved Domains (1) summary
    pfam00046
    Location:151205
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    203811582..203813122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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