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Ptpn11 protein tyrosine phosphatase, non-receptor type 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25622, updated on 4-Jan-2025

Summary

Official Symbol
Ptpn11provided by RGD
Official Full Name
protein tyrosine phosphatase, non-receptor type 11provided by RGD
Primary source
RGD:3447
See related
EnsemblRapid:ENSRNOG00000030124 AllianceGenome:RGD:3447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Shp2
Summary
Enables several functions, including insulin receptor substrate binding activity; phospholipase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to peptide hormone stimulus; and positive regulation of focal adhesion assembly. Located in plasma membrane raft. Part of protein-containing complex. Used to study glaucoma. Biomarker of glaucoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 599.9), Muscle (RPKM 483.6) and 9 other tissues See more
Orthologs
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Genomic context

See Ptpn11 in Genome Data Viewer
Location:
12q16
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41026079..41085577)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35365436..35424925)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40895515..40955999)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene TRAF type zinc finger domain containing 1 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene ribosomal protein L6 Neighboring gene uncharacterized LOC134481334 Neighboring gene rabphilin 3A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 37
Function Evidence Code Pubs
enables D1 dopamine receptor binding PubMed 
enables cadherin binding  
enables cadherin binding  
enables cell adhesion molecule binding  
enables cell adhesion molecule binding PubMed 
enables cell adhesion molecule binding  
enables histone H2AXY142 phosphatase activity  
enables insulin receptor binding PubMed 
enables insulin receptor binding  
enables insulin receptor binding  
enables insulin receptor substrate binding PubMed 
enables molecular adaptor activity  
enables non-membrane spanning protein tyrosine phosphatase activity  
enables non-membrane spanning protein tyrosine phosphatase activity  
enables non-membrane spanning protein tyrosine phosphatase activity  
enables non-membrane spanning protein tyrosine phosphatase activity  
enables peptide hormone receptor binding  
enables peptide hormone receptor binding  
enables phospholipase binding PubMed 
enables phosphoprotein phosphatase activity  
enables phosphotyrosine residue binding  
enables phosphotyrosine residue binding  
enables protein binding PubMed 
enables protein domain specific binding PubMed 
enables protein kinase binding  
enables protein tyrosine kinase binding PubMed 
enables protein tyrosine kinase binding  
enables protein tyrosine phosphatase activity PubMed 
enables protein tyrosine phosphatase activity  
enables protein tyrosine phosphatase activity  
enables protein tyrosine phosphatase activity, metal-dependent  
enables receptor tyrosine kinase binding  
enables receptor tyrosine kinase binding  
enables receptor tyrosine kinase binding PubMed 
enables receptor tyrosine kinase binding  
enables signaling receptor complex adaptor activity  
enables signaling receptor complex adaptor activity  
Items 1 - 25 of 37
Items 1 - 25 of 118
Process Evidence Code Pubs
involved_in Bergmann glial cell differentiation  
acts_upstream_of_or_within Bergmann glial cell differentiation  
involved_in DNA damage checkpoint signaling  
acts_upstream_of_or_within DNA damage checkpoint signaling  
involved_in ERBB signaling pathway  
involved_in ERBB signaling pathway  
involved_in atrioventricular canal development  
involved_in atrioventricular canal development  
involved_in axonogenesis  
acts_upstream_of_or_within axonogenesis  
involved_in brain development  
involved_in cellular response to angiotensin PubMed 
involved_in cellular response to epidermal growth factor stimulus  
involved_in cellular response to epidermal growth factor stimulus  
involved_in cellular response to epidermal growth factor stimulus  
involved_in cellular response to hydrogen peroxide PubMed 
involved_in cellular response to insulin-like growth factor stimulus PubMed 
involved_in cellular response to mechanical stimulus PubMed 
involved_in cerebellar cortex formation  
acts_upstream_of_or_within cerebellar cortex formation  
involved_in chromatin remodeling  
involved_in ephrin receptor signaling pathway  
involved_in ephrin receptor signaling pathway  
involved_in ephrin receptor signaling pathway  
involved_in epidermal growth factor receptor signaling pathway  
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway  
involved_in epidermal growth factor receptor signaling pathway  
involved_in face morphogenesis  
involved_in face morphogenesis  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in genitalia development  
involved_in genitalia development  
involved_in glucose homeostasis  
acts_upstream_of_or_within glucose homeostasis  
involved_in heart development  
involved_in homeostasis of number of cells within a tissue  
acts_upstream_of_or_within homeostasis of number of cells within a tissue  
involved_in hormone metabolic process  
acts_upstream_of_or_within hormone metabolic process  
involved_in hormone-mediated signaling pathway  
acts_upstream_of_or_within hormone-mediated signaling pathway  
involved_in inner ear development  
involved_in inner ear development  
involved_in integrin-mediated signaling pathway  
acts_upstream_of_or_within integrin-mediated signaling pathway  
involved_in intestinal epithelial cell migration  
acts_upstream_of_or_within intestinal epithelial cell migration  
acts_upstream_of_or_within lipid metabolic process  
involved_in megakaryocyte development  
acts_upstream_of_or_within megakaryocyte development  
involved_in microvillus organization  
acts_upstream_of_or_within microvillus organization  
involved_in multicellular organism growth  
acts_upstream_of_or_within multicellular organism growth  
involved_in negative regulation of cell adhesion mediated by integrin  
acts_upstream_of_or_within negative regulation of cell adhesion mediated by integrin  
involved_in negative regulation of chondrocyte differentiation  
involved_in negative regulation of chondrocyte differentiation  
involved_in negative regulation of chondrocyte differentiation  
involved_in negative regulation of cortisol secretion  
acts_upstream_of_or_within negative regulation of cortisol secretion  
involved_in negative regulation of growth hormone secretion  
acts_upstream_of_or_within negative regulation of growth hormone secretion  
acts_upstream_of_or_within negative regulation of hormone secretion  
involved_in negative regulation of insulin secretion  
acts_upstream_of_or_within negative regulation of insulin secretion  
involved_in negative regulation of neutrophil activation  
involved_in negative regulation of type I interferon production  
involved_in negative regulation of type I interferon production  
involved_in neurotrophin TRK receptor signaling pathway  
acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway  
involved_in organ growth  
acts_upstream_of_or_within organ growth  
involved_in peptidyl-tyrosine dephosphorylation  
involved_in peptidyl-tyrosine dephosphorylation  
involved_in platelet formation  
acts_upstream_of_or_within platelet formation  
involved_in platelet-derived growth factor receptor signaling pathway  
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway  
involved_in positive regulation of D-glucose import  
involved_in positive regulation of D-glucose import  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade  
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of focal adhesion assembly PubMed 
involved_in positive regulation of hormone secretion  
acts_upstream_of_or_within positive regulation of hormone secretion  
involved_in positive regulation of insulin receptor signaling pathway  
involved_in positive regulation of insulin receptor signaling pathway  
involved_in positive regulation of interferon-beta production  
involved_in positive regulation of interferon-beta production  
involved_in positive regulation of interleukin-6 production  
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway  
involved_in positive regulation of mitotic cell cycle  
acts_upstream_of_or_within positive regulation of mitotic cell cycle  
involved_in positive regulation of ossification  
involved_in positive regulation of ossification  
involved_in positive regulation of ossification  
involved_in positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of peptidyl-tyrosine phosphorylation  
acts_upstream_of_or_within positive regulation of signal transduction  
involved_in positive regulation of tumor necrosis factor production  
involved_in positive regulation of tumor necrosis factor production  
involved_in protein dephosphorylation PubMed 
acts_upstream_of_or_within regulation of MAPK cascade  
involved_in regulation of cell adhesion mediated by integrin  
involved_in regulation of cell adhesion mediated by integrin  
involved_in regulation of protein export from nucleus  
acts_upstream_of_or_within regulation of protein export from nucleus  
involved_in regulation of protein-containing complex assembly  
involved_in regulation of protein-containing complex assembly  
acts_upstream_of signal transduction  
involved_in smooth muscle cell proliferation PubMed 
involved_in triglyceride metabolic process  
acts_upstream_of_or_within triglyceride metabolic process  
Items 1 - 25 of 118
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
is_active_in cytosol  
located_in cytosol  
located_in mitochondrion PubMed 
located_in nucleus  
located_in nucleus  
located_in nucleus  
located_in plasma membrane raft PubMed 
part_of protein-containing complex PubMed 
part_of protein-containing complex  
part_of protein-containing complex  

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 11
Names
PTP-1D
SH-PTP2 protein tyrosine phosphatase, non-receptor type 11
SHP-2
encodes catalytic domain
protein tyrosine phosphatase SH-PTP2
protein-tyrosine phosphatase 1D
protein-tyrosine phosphatase SYP
NP_001171064.1
NP_037220.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177593.1NP_001171064.1  tyrosine-protein phosphatase non-receptor type 11 isoform 1

    See identical proteins and their annotated locations for NP_001171064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8L2ULP1
    Conserved Domains (4) summary
    cd09931
    Location:111218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:246524
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:276523
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_013088.2NP_037220.2  tyrosine-protein phosphatase non-receptor type 11 isoform 2

    See identical proteins and their annotated locations for NP_037220.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal 4-aa segment, compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    P41499, Q62626
    UniProtKB/TrEMBL
    A0A8L2ULP1, A6J1G3
    Related
    ENSRNOP00000041842.6, ENSRNOT00000046323.7
    Conserved Domains (3) summary
    cd09931
    Location:111218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272524
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    41026079..41085577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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