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Fdft1 farnesyl diphosphate farnesyl transferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29580, updated on 4-Jan-2025

Summary

Official Symbol
Fdft1provided by RGD
Official Full Name
farnesyl diphosphate farnesyl transferase 1provided by RGD
Primary source
RGD:61834
See related
EnsemblRapid:ENSRNOG00000021314 AllianceGenome:RGD:61834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable squalene synthase [NAD(P)H] activity. Involved in cholesterol biosynthetic process and farnesyl diphosphate metabolic process. Located in endoplasmic reticulum membrane. Used to study cataract. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 258.9), Kidney (RPKM 209.9) and 9 other tissues See more
Orthologs
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Genomic context

See Fdft1 in Genome Data Viewer
Location:
15p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (41588114..41616168, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (37412143..37440198, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (46339248..46367302, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene defensin beta 44 Neighboring gene cathepsin B Neighboring gene uncharacterized LOC134482130 Neighboring gene nei-like DNA glycosylase 2 Neighboring gene GATA binding protein 4 Neighboring gene uncharacterized LOC102548615

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Clone Names

  • MGC93486

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding  
enables squalene synthase [NAD(P)H] activity  
enables squalene synthase [NAD(P)H] activity  
Component Evidence Code Pubs
located_in endoplasmic reticulum  
located_in endoplasmic reticulum  
is_active_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane PubMed 
located_in membrane  

General protein information

Preferred Names
squalene synthase
Names
FPP:FPP farnesyltransferase
SQS
SS
farnesyl diphosphate farnesyltransferase
squalene synthetase
NP_062111.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019238.2NP_062111.1  squalene synthase

    See identical proteins and their annotated locations for NP_062111.1

    Status: VALIDATED

    Source sequence(s)
    BC081810, BE104849, JAXUCZ010000015
    UniProtKB/Swiss-Prot
    Q02769
    UniProtKB/TrEMBL
    A0A8I6GF68, A6K6F7
    Related
    ENSRNOP00000029808.3, ENSRNOT00000032089.6
    Conserved Domains (1) summary
    cl00210
    Location:39370
    Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    41588114..41616168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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