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Bcan brevican [ Rattus norvegicus (Norway rat) ]

Gene ID: 25393, updated on 4-Jan-2025

Summary

Symbol
Bcanprovided by RGD
Full Name
brevicanprovided by RGD
Primary source
RGD:2194
See related
EnsemblRapid:ENSRNOG00000018798 AllianceGenome:RGD:2194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BEHAB; ALPBRE
Summary
Predicted to enable calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Involved in cell-matrix adhesion; neurogenesis; and regulation of neuronal synaptic plasticity. Located in several cellular components, including main axon; perineuronal net; and synaptic membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and perisynaptic extracellular matrix. Used to study high grade glioma. Biomarker of high grade glioma and middle cerebral artery infarction. Orthologous to human BCAN (brevican). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 233.7) See more
Orthologs
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Genomic context

See Bcan in Genome Data Viewer
Location:
2q34
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175752333..175765766, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173454479..173467717, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187359674..187373133, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene nestin Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene G patch domain containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding  
enables carbohydrate binding  
enables hyaluronic acid binding  
Process Evidence Code Pubs
involved_in cell adhesion  
involved_in cell-matrix adhesion PubMed 
involved_in central nervous system development  
involved_in gliogenesis PubMed 
involved_in hippocampus development  
acts_upstream_of_or_within hippocampus development  
involved_in neuron projection extension PubMed 
involved_in regulation of neuronal synaptic plasticity PubMed 
involved_in skeletal system development  
involved_in synapse maturation  
involved_in synapse maturation  
Items 1 - 20 of 21
Component Evidence Code Pubs
is_active_in GABA-ergic synapse PubMed 
located_in axon PubMed 
located_in axon initial segment PubMed 
located_in cell surface PubMed 
located_in dendrite PubMed 
located_in extracellular matrix  
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
is_active_in glutamatergic synapse PubMed 
located_in glutamatergic synapse  
is_active_in glutamatergic synapse  
located_in node of Ranvier PubMed 
is_active_in perineuronal net  
located_in perineuronal net PubMed 
located_in perineuronal net  
located_in perineuronal net  
is_active_in perisynaptic extracellular matrix PubMed 
located_in side of membrane  
is_active_in synapse  
located_in synaptic membrane PubMed 
Items 1 - 20 of 21

General protein information

Preferred Names
brevican core protein
Names
brain-enriched hyaluronan-binding protein
brevican (brain specific proteoglycan in the aggrecan family)
brevican core protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033665.1NP_001028837.1  brevican core protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001028837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    CB577797, CB784255, CB810773, U37142, Z28366
    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
    UniProtKB/TrEMBL
    A6J642, G3V8G4
    Related
    ENSRNOP00000025496.4, ENSRNOT00000025496.8
    Conserved Domains (8) summary
    cd00033
    Location:791848
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03517
    Location:156250
    Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...
    cd03520
    Location:257352
    Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...
    pfam00008
    Location:626655
    EGF; EGF-like domain
    cd00096
    Location:4446
    Ig; Ig strand A' [structural motif]
    NF033913
    Location:369629
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl02432
    Location:664787
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:40158
    Ig; Immunoglobulin domain
  2. NM_012916.2NP_037048.2  brevican core protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_037048.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons in the 3' coding region and its 3' terminal exon extends past a splice site that is used in variant 1. The resulting protein (isoform 2) is shorter but has the same N-terminus compared to isoform 1.
    Source sequence(s)
    AI535159, CB577797, JAXUCZ010000002, X86406, Z28366
    UniProtKB/TrEMBL
    A6J643
    Conserved Domains (4) summary
    smart00410
    Location:43153
    IG_like; Immunoglobulin like
    cd03517
    Location:156250
    Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
    cd03520
    Location:257352
    Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
    cl11960
    Location:48157
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    175752333..175765766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101790.2XP_038957718.1  brevican core protein isoform X1

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
    Conserved Domains (8) summary
    cd00033
    Location:791848
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03517
    Location:156250
    Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...
    cd03520
    Location:257352
    Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...
    pfam00008
    Location:626655
    EGF; EGF-like domain
    cd00096
    Location:4446
    Ig; Ig strand A' [structural motif]
    NF033913
    Location:369629
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl02432
    Location:664787
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:40158
    Ig; Immunoglobulin domain
  2. XM_039101788.2XP_038957716.1  brevican core protein isoform X1

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
    Conserved Domains (8) summary
    cd00033
    Location:791848
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03517
    Location:156250
    Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...
    cd03520
    Location:257352
    Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...
    pfam00008
    Location:626655
    EGF; EGF-like domain
    cd00096
    Location:4446
    Ig; Ig strand A' [structural motif]
    NF033913
    Location:369629
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl02432
    Location:664787
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:40158
    Ig; Immunoglobulin domain
  3. XM_039101787.2XP_038957715.1  brevican core protein isoform X1

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
    Conserved Domains (8) summary
    cd00033
    Location:791848
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03517
    Location:156250
    Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...
    cd03520
    Location:257352
    Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...
    pfam00008
    Location:626655
    EGF; EGF-like domain
    cd00096
    Location:4446
    Ig; Ig strand A' [structural motif]
    NF033913
    Location:369629
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl02432
    Location:664787
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:40158
    Ig; Immunoglobulin domain
  4. XM_063281348.1XP_063137418.1  brevican core protein isoform X4

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
    UniProtKB/TrEMBL
    A6J642, G3V8G4
  5. XM_063281346.1XP_063137416.1  brevican core protein isoform X4

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
    UniProtKB/TrEMBL
    A6J642, G3V8G4
  6. XM_063281344.1XP_063137414.1  brevican core protein isoform X4

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
    UniProtKB/TrEMBL
    A6J642, G3V8G4
  7. XM_063281343.1XP_063137413.1  brevican core protein isoform X1

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
  8. XM_039101786.2XP_038957714.2  brevican core protein isoform X2

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
  9. XM_063281347.1XP_063137417.1  brevican core protein isoform X4

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
    UniProtKB/TrEMBL
    A6J642, G3V8G4
  10. XM_039101784.2XP_038957712.1  brevican core protein isoform X1

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
    Conserved Domains (8) summary
    cd00033
    Location:791848
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03517
    Location:156250
    Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...
    cd03520
    Location:257352
    Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...
    pfam00008
    Location:626655
    EGF; EGF-like domain
    cd00096
    Location:4446
    Ig; Ig strand A' [structural motif]
    NF033913
    Location:369629
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl02432
    Location:664787
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:40158
    Ig; Immunoglobulin domain
  11. XM_039101789.2XP_038957717.1  brevican core protein isoform X1

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
    Conserved Domains (8) summary
    cd00033
    Location:791848
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03517
    Location:156250
    Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...
    cd03520
    Location:257352
    Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...
    pfam00008
    Location:626655
    EGF; EGF-like domain
    cd00096
    Location:4446
    Ig; Ig strand A' [structural motif]
    NF033913
    Location:369629
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl02432
    Location:664787
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:40158
    Ig; Immunoglobulin domain
  12. XM_063281349.1XP_063137419.1  brevican core protein isoform X3

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
  13. XM_063281342.1XP_063137412.1  brevican core protein isoform X3

    UniProtKB/Swiss-Prot
    P55068, Q62860, Q63040, Q63513
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