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Naca nascent polypeptide associated complex subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 288770, updated on 4-Jan-2025

Summary

Official Symbol
Nacaprovided by RGD
Official Full Name
nascent polypeptide associated complex subunit alphaprovided by RGD
Primary source
RGD:1308642
See related
EnsemblRapid:ENSRNOG00000002632 AllianceGenome:RGD:1308642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable TBP-class protein binding activity; transcription coactivator activity; and unfolded protein binding activity. Predicted to be involved in negative regulation of protein localization to endoplasmic reticulum and protein targeting to membrane. Predicted to act upstream of or within myoblast migration. Predicted to be located in nucleus. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. Orthologous to human NACA (nascent polypeptide associated complex subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 363.8), Spleen (RPKM 353.3) and 9 other tissues See more
Orthologs
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Genomic context

See Naca in Genome Data Viewer
Location:
7q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1053474..1066606)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (468862..481992)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2458283..2470674)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene 17-beta-hydroxysteroid dehydrogenase type 6-like Neighboring gene transfer RNA proline (anticodon GGG) Neighboring gene DNA primase subunit 1 Neighboring gene prostaglandin E synthase 3 Neighboring gene uncharacterized LOC120093524 Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene ATP synthase F1 subunit beta

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables TBP-class protein binding  
enables transcription coactivator activity  
enables unfolded protein binding  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
part_of nascent polypeptide-associated complex  
located_in nucleus  

General protein information

Preferred Names
nascent polypeptide-associated complex subunit alpha
Names
nascent polypeptide-associated complex alpha subunit
nascent-polypeptide-associated complex alpha polypeptide
NP_001099409.1
NP_001185491.1
NP_001185509.1
XP_038934468.1
XP_038934469.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105939.2NP_001099409.1  nascent polypeptide-associated complex subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_001099409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2KAT8, B2RYX0
    Related
    ENSRNOP00000075523.3, ENSRNOT00000085092.3
    Conserved Domains (2) summary
    cd14415
    Location:169214
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    cd22054
    Location:84131
    NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
  2. NM_001198562.2NP_001185491.1  nascent polypeptide-associated complex subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_001185491.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2KAT8, B2RYX0
    Related
    ENSRNOP00000003550.6, ENSRNOT00000003550.9
    Conserved Domains (2) summary
    cd14415
    Location:169214
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    cd22054
    Location:84131
    NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
  3. NM_001198580.1NP_001185509.1  nascent polypeptide-associated complex subunit alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional large exon in the CDS compared to variant 1. The resulting isoform (2) has a larger internal segment compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    M0R9L0
    Related
    ENSRNOP00000099310.1, ENSRNOT00000125870.1
    Conserved Domains (3) summary
    PHA03247
    Location:10751517
    PHA03247; large tegument protein UL36; Provisional
    cd14415
    Location:21172162
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    cd22054
    Location:20322079
    NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    1053474..1066606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078540.2XP_038934468.1  nascent polypeptide-associated complex subunit alpha isoform X1

    UniProtKB/TrEMBL
    M0R9L0
    Related
    ENSRNOP00000066181.1, ENSRNOT00000075681.5
    Conserved Domains (3) summary
    PHA03247
    Location:10751517
    PHA03247; large tegument protein UL36; Provisional
    cd14415
    Location:21172162
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    cd22054
    Location:20322079
    NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
  2. XM_039078541.2XP_038934469.1  nascent polypeptide-associated complex subunit alpha isoform X1

    UniProtKB/TrEMBL
    M0R9L0
    Conserved Domains (3) summary
    PHA03247
    Location:10751517
    PHA03247; large tegument protein UL36; Provisional
    cd14415
    Location:21172162
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    cd22054
    Location:20322079
    NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
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