U.S. flag

An official website of the United States government

Cd86 CD86 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 56822, updated on 4-Jan-2025

Summary

Official Symbol
Cd86provided by RGD
Official Full Name
CD86 moleculeprovided by RGD
Primary source
RGD:628714
See related
EnsemblRapid:ENSRNOG00000038835 AllianceGenome:RGD:628714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
B7-2
Summary
Enables signaling receptor binding activity. Involved in several processes, including defense response to symbiont; negative regulation of T cell anergy; and positive regulation of activated T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia/lymphoma and bronchiolitis obliterans. Biomarker of asthma; corneal disease; middle cerebral artery infarction; and orchitis. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 119.3), Thymus (RPKM 50.8) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cd86 in Genome Data Viewer
Location:
11q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (77647565..77706178)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (64142193..64200816)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (67060305..67117990)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene RNA guanylyltransferase and 5'-phosphatase, pseudogene 1 Neighboring gene immunoglobulin-like domain containing receptor 1 Neighboring gene uncharacterized LOC134481008 Neighboring gene calcium-sensing receptor Neighboring gene stefin A3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 29
Process Evidence Code Pubs
acts_upstream_of_or_within B cell activation  
involved_in B cell activation  
involved_in T cell activation  
involved_in T cell costimulation  
involved_in T cell proliferation involved in immune response PubMed 
involved_in cell surface receptor signaling pathway  
involved_in cellular response to cytokine stimulus PubMed 
involved_in cellular response to lipopolysaccharide  
involved_in cellular response to lipopolysaccharide PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide  
involved_in cellular response to metal ion PubMed 
involved_in defense response to virus PubMed 
acts_upstream_of_or_within defense response to virus  
involved_in immune response  
involved_in myeloid dendritic cell differentiation PubMed 
involved_in negative regulation of T cell anergy PubMed 
involved_in negative regulation of T cell proliferation  
involved_in positive regulation of T cell proliferation  
involved_in positive regulation of T cell proliferation PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation  
involved_in positive regulation of activated T cell proliferation PubMed 
involved_in positive regulation of immunoglobulin production  
involved_in positive regulation of non-canonical NF-kappaB signal transduction  
involved_in response to lipopolysaccharide PubMed 
involved_in response to type II interferon PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in response to yeast PubMed 
involved_in toll-like receptor 3 signaling pathway  
acts_upstream_of_or_within toll-like receptor signaling pathway  
Items 1 - 25 of 29
Component Evidence Code Pubs
located_in cell surface PubMed 
located_in centriolar satellite  
is_active_in external side of plasma membrane  
located_in external side of plasma membrane  
located_in extracellular exosome  
located_in intracellular membrane-bounded organelle  
located_in plasma membrane  

General protein information

Preferred Names
T-lymphocyte activation antigen CD86
Names
cd86 antigen
membrane glycoprotein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020081.3NP_064466.1  T-lymphocyte activation antigen CD86 precursor

    See identical proteins and their annotated locations for NP_064466.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A0G2JXF7, A0A8J8XMF6, A0A9K3Y6P6, F1LNG0, O35531
    Related
    ENSRNOP00000070253.2, ENSRNOT00000078936.3
    Conserved Domains (2) summary
    smart00406
    Location:40117
    IGv; Immunoglobulin V-Type
    cl11960
    Location:143224
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    77647565..77706178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248399.5XP_006248461.1  T-lymphocyte activation antigen CD86 isoform X1

    See identical proteins and their annotated locations for XP_006248461.1

    UniProtKB/TrEMBL
    A0A8J8XMF6, A6IRC5
    Related
    ENSRNOP00000101190.1, ENSRNOT00000159927.1
    Conserved Domains (3) summary
    cd00096
    Location:133139
    Ig; Ig strand A [structural motif]
    cd16087
    Location:20127
    IgV_CD86; Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86
    cl11960
    Location:130213
    Ig; Immunoglobulin domain
  2. XM_039088600.2XP_038944528.1  T-lymphocyte activation antigen CD86 isoform X1

    UniProtKB/TrEMBL
    A0A8J8XMF6, A6IRC5
    Conserved Domains (3) summary
    cd00096
    Location:133139
    Ig; Ig strand A [structural motif]
    cd16087
    Location:20127
    IgV_CD86; Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86
    cl11960
    Location:130213
    Ig; Immunoglobulin domain
External link. Please review our privacy policy.