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Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361384, updated on 4-Jan-2025

Summary

Official Symbol
Dnajb1provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member B1provided by RGD
Primary source
RGD:1304725
See related
AllianceGenome:RGD:1304725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATPase binding activity; Hsp70 protein binding activity; and transcription regulator inhibitor activity. Involved in forebrain development. Located in dendritic spine; neuronal cell body; and sperm head. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 393.0), Adrenal (RPKM 203.5) and 9 other tissues See more
Orthologs
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Genomic context

See Dnajb1 in Genome Data Viewer
Location:
19q11
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41427453..41431141, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24522731..24526419, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (24747178..24750919)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene GIPC PDZ domain containing family, member 1 Neighboring gene cytochrome c-like Neighboring gene ribosomal protein S10, pseudogene 10 Neighboring gene trans-2,3-enoyl-CoA reductase Neighboring gene ribosomal protein S2, pseudogene 7 Neighboring gene uncharacterized LOC134483333

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase activator activity  
enables ATPase binding  
enables Hsp70 protein binding  
enables Hsp70 protein binding  
enables protein folding chaperone  
enables protein-folding chaperone binding  
enables transcription corepressor activity  
enables transcription corepressor activity  
enables transcription regulator inhibitor activity  
enables unfolded protein binding  
enables unfolded protein binding  
Component Evidence Code Pubs
located_in cytoplasm  
is_active_in cytosol  
located_in cytosol  
located_in dendritic spine PubMed 
is_active_in glutamatergic synapse PubMed 
located_in neuronal cell body PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in postsynapse PubMed 
is_active_in postsynaptic density PubMed 
located_in sperm head PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily B member 1
Names
DnaJ (Hsp40) homolog, subfamily B, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395149.1NP_001382078.1  dnaJ homolog subfamily B member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    B0K030
    Conserved Domains (1) summary
    COG0484
    Location:1340
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    41427453..41431141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601314.3XP_017456803.2  dnaJ homolog subfamily B member 1 isoform X1

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