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    Dhx15 DEAH-box helicase 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289693, updated on 4-Jan-2025

    Summary

    Symbol
    Dhx15provided by RGD
    Full Name
    DEAH-box helicase 15provided by RGD
    Primary source
    RGD:1308072
    See related
    EnsemblRapid:ENSRNOG00000003844 AllianceGenome:RGD:1308072
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA helicase activity and double-stranded RNA binding activity. Involved in response to alkaloid and response to toxic substance. Predicted to be located in nuclear speck. Predicted to be part of U12-type spliceosomal complex and U2-type post-mRNA release spliceosomal complex. Orthologous to human DHX15 (DEAH-box helicase 15). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 807.7), Spleen (RPKM 550.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dhx15 in Genome Data Viewer
    Location:
    14q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (62999886..63037829)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (58787147..58825083)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (61136740..61174880)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481756 Neighboring gene uncharacterized LOC108352757 Neighboring gene ribosomal protein L36, pseudogene Neighboring gene PPARG coactivator 1 alpha Neighboring gene high mobility group nucleosome binding domain 1, pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables RNA binding  
    enables RNA binding  
    enables RNA helicase activity  
    enables double-stranded RNA binding  
    enables helicase activity  
    enables hydrolase activity  
    Process Evidence Code Pubs
    involved_in RNA splicing  
    involved_in antiviral innate immune response  
    involved_in defense response to bacterium  
    involved_in defense response to virus  
    involved_in mRNA processing  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in response to alkaloid PubMed 
    involved_in response to toxic substance PubMed 
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex  
    part_of U2-type post-mRNA release spliceosomal complex  
    located_in membrane  
    located_in nuclear speck  
    located_in nuclear speck  
    part_of spliceosomal complex  

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DHX15
    Names
    DEAH (Asp-Glu-Ala-His) box helicase 15
    DEAH (Asp-Glu-Ala-His) box polypeptide 15
    pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15-like
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15-like
    NP_001178526.1
    XP_063129005.1
    XP_063129006.1
    XP_063129007.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191597.1NP_001178526.1  ATP-dependent RNA helicase DHX15

      See identical proteins and their annotated locations for NP_001178526.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6IJI2, D3ZD97
      Related
      ENSRNOP00000005126.6, ENSRNOT00000005126.8
      Conserved Domains (1) summary
      COG1643
      Location:124763
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      62999886..63037829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272935.1XP_063129005.1  ATP-dependent RNA helicase DHX15 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZT94
    2. XM_063272936.1XP_063129006.1  ATP-dependent RNA helicase DHX15 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZT94
    3. XM_063272937.1XP_063129007.1  ATP-dependent RNA helicase DHX15 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZT94
      Related
      ENSRNOP00000081583.1, ENSRNOT00000103809.2

    RNA

    1. XR_005492917.2 RNA Sequence

    2. XR_005492918.2 RNA Sequence

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