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Anxa7 annexin A7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 155423, updated on 4-Jan-2025

Summary

Official Symbol
Anxa7provided by RGD
Official Full Name
annexin A7provided by RGD
Primary source
RGD:621173
See related
EnsemblRapid:ENSRNOG00000007136 AllianceGenome:RGD:621173
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium-dependent phospholipid binding activity. Involved in membrane fusion; response to calcium ion; and response to organic cyclic compound. Predicted to be located in several cellular components, including chromaffin granule membrane; endoplasmic reticulum membrane; and nuclear envelope. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Orthologous to human ANXA7 (annexin A7). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 133.9), Spleen (RPKM 133.2) and 9 other tissues See more
Orthologs
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Genomic context

See Anxa7 in Genome Data Viewer
Location:
15p16
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (3869180..3897827)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (3821798..3849659)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (4254470..4281296)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693236 Neighboring gene protein phosphatase 3 catalytic subunit beta Neighboring gene 60S ribosomal protein L15-like Neighboring gene uncharacterized LOC134482077 Neighboring gene MSS51 mitochondrial translational activator Neighboring gene cilia and flagella associated protein 70 Neighboring gene mitochondrial ribosomal protein S16

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase-dependent fusogenic activity  
enables calcium ion binding  
enables calcium-dependent phospholipid binding  
enables calcium-dependent phospholipid binding PubMed 
enables calcium-dependent protein binding  
enables integrin binding  
enables phosphatidylserine binding  
Process Evidence Code Pubs
involved_in autophagy  
involved_in epithelial cell differentiation  
acts_upstream_of establishment of localization in cell  
acts_upstream_of_or_within glial cell proliferation  
acts_upstream_of_or_within hemostasis  
acts_upstream_of insulin secretion  
acts_upstream_of_or_within intracellular calcium ion homeostasis  
acts_upstream_of_or_within intracellular water homeostasis  
acts_upstream_of_or_within_positive_effect ion channel modulating, G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within_positive_effect ligand-gated ion channel signaling pathway  
involved_in membrane fusion PubMed 
involved_in negative regulation of gene expression  
acts_upstream_of_or_within_positive_effect phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  
acts_upstream_of_or_within_positive_effect positive regulation of insulin secretion  
acts_upstream_of_or_within regulation of cell shape  
involved_in response to calcium ion PubMed 
involved_in response to organic cyclic compound PubMed 
acts_upstream_of_or_within response to salt stress  
Component Evidence Code Pubs
located_in chromaffin granule membrane  
is_active_in cytoplasm  
located_in cytosol  
located_in endoplasmic reticulum membrane  
located_in nuclear envelope  
is_active_in nucleus  
located_in nucleus  
is_active_in plasma membrane  
located_in plasma membrane  
located_in synapse  
located_in vesicle  
is_active_in vesicle membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130416.2NP_569100.2  annexin A7

    See identical proteins and their annotated locations for NP_569100.2

    Status: PROVISIONAL

    Source sequence(s)
    BC070896
    UniProtKB/TrEMBL
    A0A8I5ZQ42, Q6IRJ7, Q8VIN2
    Related
    ENSRNOP00000090513.2, ENSRNOT00000108222.2
    Conserved Domains (1) summary
    pfam00191
    Location:164229
    Annexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    3869180..3897827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251626.5XP_006251688.1  annexin A7 isoform X2

    See identical proteins and their annotated locations for XP_006251688.1

    UniProtKB/TrEMBL
    F7F6D1, Q8VIN2
    Conserved Domains (1) summary
    pfam00191
    Location:186251
    Annexin
  2. XM_006251625.5XP_006251687.1  annexin A7 isoform X2

    See identical proteins and their annotated locations for XP_006251687.1

    UniProtKB/TrEMBL
    F7F6D1, Q8VIN2
    Related
    ENSRNOP00000080216.2, ENSRNOT00000104138.2
    Conserved Domains (1) summary
    pfam00191
    Location:186251
    Annexin
  3. XM_006251627.5XP_006251689.3  annexin A7 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A9P3, Q8VIN2
  4. XM_063273920.1XP_063129990.1  annexin A7 isoform X2

    UniProtKB/TrEMBL
    F7F6D1, Q8VIN2
  5. XM_006251624.5XP_006251686.3  annexin A7 isoform X1

    UniProtKB/TrEMBL
    Q8VIN2
    Related
    ENSRNOP00000058397.4, ENSRNOT00000061686.5
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