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Morc2 MORC family CW-type zinc finger 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289736, updated on 4-Jan-2025

Summary

Official Symbol
Morc2provided by RGD
Official Full Name
MORC family CW-type zinc finger 2provided by RGD
Primary source
RGD:1310842
See related
EnsemblRapid:ENSRNOG00000019624 AllianceGenome:RGD:1310842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Morc2a; Zcwcc1
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and metal ion binding activity. Predicted to be involved in DNA damage response; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and transposable element silencing by heterochromatin formation. Predicted to be located in cytosol; heterochromatin; and nuclear lumen. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 101.9), Thymus (RPKM 85.3) and 9 other tissues See more
Orthologs
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Genomic context

See Morc2 in Genome Data Viewer
Location:
14q21
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (82752444..82794980)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78529603..78571375)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (83889138..83930263)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352784 Neighboring gene taurine up-regulated 1 Neighboring gene taurine up-regulated 1 Neighboring gene oxysterol binding protein 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134481865

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables ATP hydrolysis activity  
enables chromatin binding  
enables histone binding  
enables identical protein binding  
enables magnesium ion binding  
enables protein homodimerization activity  
enables zinc ion binding  
Component Evidence Code Pubs
located_in cytoplasm  
located_in cytosol  
located_in heterochromatin  
located_in nuclear matrix  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus  

General protein information

Preferred Names
ATPase MORC2
Names
MORC family CW-type zinc finger protein 2
microrchidia 2A
zinc finger, CW-type with coiled-coil domain 1
NP_001402037.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415108.1 → NP_001402037.1  ATPase MORC2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    D4A2C4
    Related
    ENSRNOP00000069862.3, ENSRNOT00000078980.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    82752444..82794980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005492921.2 RNA Sequence

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