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Prpf8 pre-mRNA processing factor 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287530, updated on 4-Jan-2025

Summary

Official Symbol
Prpf8provided by RGD
Official Full Name
pre-mRNA processing factor 8provided by RGD
Primary source
RGD:1305467
See related
EnsemblRapid:ENSRNOG00000003495 AllianceGenome:RGD:1305467
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; pre-mRNA intronic binding activity; and snRNA binding activity. Involved in cellular response to lipopolysaccharide and cellular response to tumor necrosis factor. Part of small nuclear ribonucleoprotein complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 13. Orthologous to human PRPF8 (pre-mRNA processing factor 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 436.8), Kidney (RPKM 391.0) and 9 other tissues See more
Orthologs
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Genomic context

See Prpf8 in Genome Data Viewer
Location:
10q24
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60829778..60852887)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (60331494..60354606)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (63635239..63658360)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microRNA 22 Neighboring gene TLC domain containing 2 Neighboring gene Rab interacting lysosomal protein Neighboring gene scavenger receptor class F, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding  
enables U1 snRNA binding  
enables U2 snRNA binding  
enables U5 snRNA binding  
enables U6 snRNA binding  
enables metallopeptidase activity  
enables pre-mRNA intronic binding  
enables protein binding PubMed 
Component Evidence Code Pubs
part_of U2-type catalytic step 1 spliceosome  
part_of U2-type catalytic step 2 spliceosome  
part_of U2-type precatalytic spliceosome  
part_of U4/U6 x U5 tri-snRNP complex  
part_of U5 snRNP  
part_of catalytic step 2 spliceosome  
part_of catalytic step 2 spliceosome  
located_in nucleus  
part_of small nuclear ribonucleoprotein complex PubMed 

General protein information

Preferred Names
pre-mRNA-processing-splicing factor 8
Names
PRP8 pre-mRNA processing factor 8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191590.1NP_001178519.1  pre-mRNA-processing-splicing factor 8

    See identical proteins and their annotated locations for NP_001178519.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2K5V6, A6HGR5, G3V6H2
    Related
    ENSRNOP00000005016.3, ENSRNOT00000005016.7
    Conserved Domains (1) summary
    COG5178
    Location:12335
    PRP8; U5 snRNP spliceosome subunit [RNA processing and modification]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    60829778..60852887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246892.5XP_006246954.1  pre-mRNA-processing-splicing factor 8 isoform X1

    See identical proteins and their annotated locations for XP_006246954.1

    UniProtKB/TrEMBL
    A0A0G2K5V6, A6HGR5, G3V6H2
    Conserved Domains (1) summary
    COG5178
    Location:12335
    PRP8; U5 snRNP spliceosome subunit [RNA processing and modification]
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