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Dgcr2 DiGeorge syndrome critical region gene 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360742, updated on 4-Jan-2025

Summary

Symbol
Dgcr2provided by RGD
Full Name
DiGeorge syndrome critical region gene 2provided by RGD
Primary source
RGD:1310567
See related
EnsemblRapid:ENSRNOG00000061814 AllianceGenome:RGD:1310567
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in cognition. Predicted to act upstream of or within response to xenobiotic stimulus. Predicted to be active in membrane. Orthologous to human DGCR2 (DiGeorge syndrome critical region gene 2). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Note: GeneIDs: 360742 and 103693608 are annotated independently on Rnor_6.0 but may be redundant loci. [12 Feb 2015]
Expression
Biased expression in Thymus (RPKM 197.9), Kidney (RPKM 192.4) and 9 other tissues See more
Orthologs
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Genomic context

See Dgcr2 in Genome Data Viewer
Location:
11q23
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96598247..96648791)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83093961..83144507)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87242441..87290806)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene ess-2 splicing factor homolog Neighboring gene testis-specific serine kinase 2 Neighboring gene testis-specific serine kinase 1B Neighboring gene protein FAM246A-like Neighboring gene carbonic anhydrase 15

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell adhesion  
involved_in cognition  
acts_upstream_of_or_within response to xenobiotic stimulus  
Component Evidence Code Pubs
is_active_in membrane  
located_in membrane  

General protein information

Preferred Names
integral membrane protein DGCR2/IDD
Names
integral membrane protein DGCR2/IDD-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012146.1NP_001012146.1  integral membrane protein DGCR2/IDD precursor

    See identical proteins and their annotated locations for NP_001012146.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081905
    UniProtKB/TrEMBL
    A0A0G2JUR3, A0A8I5ZQN6, A6JSJ9, E9PTM9, Q66HD9
    Conserved Domains (3) summary
    cd03599
    Location:111263
    CLECT_DGCR2_like; C-type lectin-like domain (CTLD) of the type found in DGCR2, an integral membrane protein deleted in DiGeorge Syndrome (DGS)
    smart00214
    Location:267325
    VWC; von Willebrand factor (vWF) type C domain
    cd00112
    Location:3066
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    96598247..96648791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088526.2XP_038944454.1  integral membrane protein DGCR2/IDD isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQN6
    Related
    ENSRNOP00000069196.2, ENSRNOT00000083415.3
    Conserved Domains (3) summary
    cd03599
    Location:114266
    CLECT_DGCR2_like; C-type lectin-like domain (CTLD) of the type found in DGCR2, an integral membrane protein deleted in DiGeorge Syndrome (DGS)
    smart00214
    Location:270328
    VWC; von Willebrand factor (vWF) type C domain
    cd00112
    Location:3066
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  2. XM_039088528.2XP_038944456.1  integral membrane protein DGCR2/IDD isoform X2

    Conserved Domains (3) summary
    cd03599
    Location:114266
    CLECT_DGCR2_like; C-type lectin-like domain (CTLD) of the type found in DGCR2, an integral membrane protein deleted in DiGeorge Syndrome (DGS)
    smart00214
    Location:270328
    VWC; von Willebrand factor (vWF) type C domain
    cd00112
    Location:3066
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  3. XM_063270658.1XP_063126728.1  integral membrane protein DGCR2/IDD isoform X3

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