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Pcbp2 poly(rC) binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363005, updated on 4-Jan-2025

Summary

Official Symbol
Pcbp2provided by RGD
Official Full Name
poly(rC) binding protein 2provided by RGD
Primary source
RGD:1309626
See related
EnsemblRapid:ENSRNOG00000036852 AllianceGenome:RGD:1309626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nucleic acid binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including IRES-dependent viral translational initiation; chromatin looping; and regulation of defense response. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Is active in postsynaptic density. Orthologous to human PCBP2 (poly(rC) binding protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 199.1), Thymus (RPKM 177.1) and 9 other tissues See more
Orthologs
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Genomic context

See Pcbp2 in Genome Data Viewer
Location:
7q36
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135483702..135508254)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133605375..133631312)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144077901..144103723)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479584 Neighboring gene anti-Mullerian hormone receptor type 2 Neighboring gene proline rich 13 Neighboring gene mitogen activated protein kinase kinase kinase 12 Neighboring gene Tarbp2 subunit of RISC loading complex Neighboring gene neuropeptide FF-amide peptide precursor

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables C-rich single-stranded DNA binding  
enables DNA binding  
enables RNA binding  
enables enzyme binding  
enables lncRNA binding  
enables mRNA binding  
enables promoter-enhancer loop anchoring activity  
enables single-stranded DNA binding  
enables single-stranded DNA binding  
enables ubiquitin protein ligase binding  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
is_active_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
is_active_in nucleus  
located_in nucleus  
is_active_in postsynaptic density PubMed 
is_active_in postsynaptic density PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013223.2NP_001013241.1  poly(rC)-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2KBC5, D4ACH3, Q6AYU5
    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:284359
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    135483702..135508254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242420.4XP_006242482.1  poly(rC)-binding protein 2 isoform X21

    UniProtKB/TrEMBL
    A0A0G2KBC5
    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:280355
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
  2. XM_063263971.1XP_063120041.1  poly(rC)-binding protein 2 isoform X8

  3. XM_017595011.3XP_017450500.1  poly(rC)-binding protein 2 isoform X9

    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:250325
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
  4. XM_017595010.3XP_017450499.1  poly(rC)-binding protein 2 isoform X9

    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:250325
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
  5. XM_063263972.1XP_063120042.1  poly(rC)-binding protein 2 isoform X10

  6. XM_017595006.3XP_017450495.1  poly(rC)-binding protein 2 isoform X3

    Related
    ENSRNOP00000095172.2, ENSRNOT00000120216.2
    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:281356
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
  7. XM_063263978.1XP_063120048.1  poly(rC)-binding protein 2 isoform X14

  8. XM_039079651.2XP_038935579.1  poly(rC)-binding protein 2 isoform X30

    UniProtKB/TrEMBL
    A0A0G2KBC5
    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:249324
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
  9. XM_063263994.1XP_063120064.1  poly(rC)-binding protein 2 isoform X29

    UniProtKB/TrEMBL
    A0A0G2KBC5, A0A8I6AP00, A6KCV9
  10. XM_006242419.5XP_006242481.1  poly(rC)-binding protein 2 isoform X20

    UniProtKB/TrEMBL
    A0A0G2KBC5, A0A8I5ZS12, Q6AYU2
    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:281356
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
  11. XM_006242425.4XP_006242487.1  poly(rC)-binding protein 2 isoform X29

    UniProtKB/TrEMBL
    A0A0G2KBC5, A0A8I6AP00, A6KCV9
    Related
    ENSRNOP00000095661.2, ENSRNOT00000099581.2
    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:250325
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
  12. XM_006242427.4XP_006242489.1  poly(rC)-binding protein 2 isoform X33

    UniProtKB/TrEMBL
    A0A0G2KBC5
    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:237312
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
  13. XM_063264000.1XP_063120070.1  poly(rC)-binding protein 2 isoform X35

    UniProtKB/TrEMBL
    A0A0G2KBC5
  14. XM_006242418.4XP_006242480.1  poly(rC)-binding protein 2 isoform X20

    UniProtKB/TrEMBL
    A0A0G2KBC5, A0A8I5ZS12, Q6AYU2
    Related
    ENSRNOP00000081612.1, ENSRNOT00000111669.2
    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:281356
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
  15. XM_063263975.1XP_063120045.1  poly(rC)-binding protein 2 isoform X12

  16. XM_063263976.1XP_063120046.1  poly(rC)-binding protein 2 isoform X13

  17. XM_063263980.1XP_063120050.1  poly(rC)-binding protein 2 isoform X17

  18. XM_063263963.1XP_063120033.1  poly(rC)-binding protein 2 isoform X1

  19. XM_063263962.1XP_063120032.1  poly(rC)-binding protein 2 isoform X1

  20. XM_063263965.1XP_063120035.1  poly(rC)-binding protein 2 isoform X2

  21. XM_063263974.1XP_063120044.1  poly(rC)-binding protein 2 isoform X11

  22. XM_063263969.1XP_063120039.1  poly(rC)-binding protein 2 isoform X6

  23. XM_006242422.4XP_006242484.1  poly(rC)-binding protein 2 isoform X24

    UniProtKB/TrEMBL
    A0A0G2KBC5, A0A8I6AGT9, A6KCV8
    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:268343
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
  24. XM_063263989.1XP_063120059.1  poly(rC)-binding protein 2 isoform X25

    UniProtKB/TrEMBL
    A0A0G2KBC5
  25. XM_063264003.1XP_063120073.1  poly(rC)-binding protein 2 isoform X36

    UniProtKB/TrEMBL
    A0A0G2KBC5
  26. XM_063263966.1XP_063120036.1  poly(rC)-binding protein 2 isoform X4

  27. XM_063263970.1XP_063120040.1  poly(rC)-binding protein 2 isoform X7

    Related
    ENSRNOP00000085087.2, ENSRNOT00000105769.2
  28. XM_017595014.3XP_017450503.1  poly(rC)-binding protein 2 isoform X15

    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:236311
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
  29. XM_063263979.1XP_063120049.1  poly(rC)-binding protein 2 isoform X16

  30. XM_063263973.1XP_063120043.1  poly(rC)-binding protein 2 isoform X10

  31. XM_063263967.1XP_063120037.1  poly(rC)-binding protein 2 isoform X5

  32. XM_063263983.1XP_063120053.1  poly(rC)-binding protein 2 isoform X21

    UniProtKB/TrEMBL
    A0A0G2KBC5
  33. XM_063263988.1XP_063120058.1  poly(rC)-binding protein 2 isoform X24

    UniProtKB/TrEMBL
    A0A0G2KBC5, A0A8I6AGT9, A6KCV8
  34. XM_063263990.1XP_063120060.1  poly(rC)-binding protein 2 isoform X26

    UniProtKB/TrEMBL
    A0A0G2KBC5
    Related
    ENSRNOP00000093976.2, ENSRNOT00000109477.2
  35. XM_063263995.1XP_063120065.1  poly(rC)-binding protein 2 isoform X30

    UniProtKB/TrEMBL
    A0A0G2KBC5
  36. XM_063263998.1XP_063120068.1  poly(rC)-binding protein 2 isoform X33

    UniProtKB/TrEMBL
    A0A0G2KBC5
  37. XM_063264001.1XP_063120071.1  poly(rC)-binding protein 2 isoform X35

    UniProtKB/TrEMBL
    A0A0G2KBC5
  38. XM_063263999.1XP_063120069.1  poly(rC)-binding protein 2 isoform X34

    UniProtKB/TrEMBL
    A0A0G2KBC5, A6KCW0
  39. XM_063264004.1XP_063120074.1  poly(rC)-binding protein 2 isoform X36

    UniProtKB/TrEMBL
    A0A0G2KBC5
  40. XM_017595007.3XP_017450496.1  poly(rC)-binding protein 2 isoform X3

    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:281356
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
  41. XM_063263981.1XP_063120051.1  poly(rC)-binding protein 2 isoform X18

    UniProtKB/TrEMBL
    A0A0G2KBC5
  42. XM_063263982.1XP_063120052.1  poly(rC)-binding protein 2 isoform X19

    UniProtKB/TrEMBL
    A0A0G2KBC5, D4ACH3, Q6AYU5
  43. XM_063263987.1XP_063120057.1  poly(rC)-binding protein 2 isoform X23

    UniProtKB/TrEMBL
    A0A0G2KBC5
  44. XM_063263991.1XP_063120061.1  poly(rC)-binding protein 2 isoform X27

    UniProtKB/TrEMBL
    A0A0G2KBC5, Q4V8F6
  45. XM_063263992.1XP_063120062.1  poly(rC)-binding protein 2 isoform X28

    UniProtKB/TrEMBL
    A0A0G2KBC5
  46. XM_063263986.1XP_063120056.1  poly(rC)-binding protein 2 isoform X22

    UniProtKB/TrEMBL
    A0A0G2KBC5
  47. XM_063263996.1XP_063120066.1  poly(rC)-binding protein 2 isoform X31

    UniProtKB/TrEMBL
    A0A0G2KBC5
  48. XM_063263997.1XP_063120067.1  poly(rC)-binding protein 2 isoform X32

    UniProtKB/TrEMBL
    A0A0G2KBC5
  49. XM_063263964.1XP_063120034.1  poly(rC)-binding protein 2 isoform X1

  50. XM_063263985.1XP_063120055.1  poly(rC)-binding protein 2 isoform X21

    UniProtKB/TrEMBL
    A0A0G2KBC5
    Related
    ENSRNOP00000052173.4, ENSRNOT00000055302.5
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