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    Casp1 caspase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25166, updated on 4-Jan-2025

    Summary

    Official Symbol
    Casp1provided by RGD
    Official Full Name
    caspase 1provided by RGD
    Primary source
    RGD:2274
    See related
    EnsemblRapid:ENSRNOG00000007372 AllianceGenome:RGD:2274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ice; p45; Il1bc
    Summary
    Enables scaffold protein binding activity. Involved in several processes, including microglial cell activation; positive regulation of circadian sleep/wake cycle, non-REM sleep; and positive regulation of interleukin-1 beta production. Part of protein-containing complex. Used to study acute kidney failure. Biomarker of myocardial infarction. Orthologous to human CASP1 (caspase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 365.4), Lung (RPKM 223.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Casp1 in Genome Data Viewer
    Location:
    8q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (10746338..10882295)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (2587812..2597403)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (2605743..2614637)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094074 Neighboring gene uncharacterized LOC134479988 Neighboring gene uncharacterized LOC134479989 Neighboring gene caspase 4 Neighboring gene uncharacterized LOC102557277

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CARD domain binding  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type endopeptidase activity  
    enables cytokine binding  
    enables endopeptidase activity  
    enables identical protein binding  
    enables kinase binding  
    enables peptidase activity  
    enables protein binding PubMed 
    enables scaffold protein binding PubMed 
    Items 1 - 25 of 75
    Process Evidence Code Pubs
    involved_in AIM2 inflammasome complex assembly  
    involved_in AIM2 inflammasome complex assembly  
    involved_in apoptotic process  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to mechanical stimulus  
    involved_in cellular response to type II interferon  
    involved_in cytokine precursor processing  
    involved_in defense response to Gram-negative bacterium  
    involved_in defense response to Gram-negative bacterium  
    involved_in defense response to bacterium  
    involved_in inflammatory response  
    involved_in lung development PubMed 
    involved_in membrane hyperpolarization  
    acts_upstream_of_or_within membrane hyperpolarization  
    involved_in memory PubMed 
    involved_in microglial cell activation PubMed 
    involved_in midgut development PubMed 
    involved_in mitochondrial depolarization  
    acts_upstream_of_or_within mitochondrial depolarization  
    involved_in myoblast fusion PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of cytokine production PubMed 
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of interleukin-1 alpha production  
    acts_upstream_of_or_within positive regulation of interleukin-1 alpha production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-18 production  
    involved_in positive regulation of macrophage cytokine production  
    acts_upstream_of_or_within positive regulation of macrophage cytokine production  
    involved_in positive regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in programmed necrotic cell death  
    acts_upstream_of_or_within programmed necrotic cell death  
    involved_in protein autoprocessing  
    involved_in protein autoprocessing  
    involved_in protein autoprocessing  
    involved_in protein maturation  
    acts_upstream_of_or_within protein processing  
    involved_in proteolysis  
    involved_in proteolysis  
    involved_in pyroptotic inflammatory response  
    acts_upstream_of_or_within pyroptotic inflammatory response  
    involved_in pyroptotic inflammatory response  
    involved_in pyroptotic inflammatory response  
    involved_in regulation of autophagy  
    acts_upstream_of_or_within regulation of autophagy  
    involved_in regulation of inflammatory response  
    acts_upstream_of_or_within regulation of inflammatory response  
    involved_in regulation of inflammatory response  
    involved_in regulation of inflammatory response  
    involved_in response to ATP  
    acts_upstream_of_or_within response to ATP  
    involved_in response to bacterium  
    acts_upstream_of_or_within response to bacterium  
    involved_in response to hypoxia PubMed 
    involved_in response to hypoxia  
    acts_upstream_of_or_within response to hypoxia  
    involved_in response to lipopolysaccharide  
    involved_in response to lipopolysaccharide PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide  
    involved_in response to organic cyclic compound PubMed 
    involved_in response to toxic substance PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in signaling receptor ligand precursor processing  
    Items 1 - 25 of 75
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    part_of AIM2 inflammasome complex  
    part_of AIM2 inflammasome complex  
    part_of AIM2 inflammasome complex  
    part_of IPAF inflammasome complex  
    part_of IPAF inflammasome complex  
    part_of IPAF inflammasome complex  
    part_of IPAF inflammasome complex  
    part_of NLRP1 inflammasome complex  
    part_of NLRP1 inflammasome complex  
    part_of NLRP3 inflammasome complex  
    part_of NLRP3 inflammasome complex  
    part_of NLRP3 inflammasome complex  
    part_of canonical inflammasome complex  
    is_active_in cytoplasm  
    is_active_in cytosol  
    located_in extracellular region  
    located_in extracellular region  
    located_in mitochondrion  
    located_in plasma membrane  
    part_of protease inhibitor complex  
    part_of protein-containing complex PubMed 
    part_of protein-containing complex  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    caspase-1
    Names
    IL-1 beta-converting enzyme
    Interleukin 1beta converting enzyme
    interleukin 1, beta, convertase
    interleukin-1 beta-converting enzyme
    NP_036894.3
    XP_063121014.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012762.3NP_036894.3  caspase-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P43527
      UniProtKB/TrEMBL
      A6KQJ8, F1LQZ4
      Related
      ENSRNOP00000086752.2, ENSRNOT00000098719.2
      Conserved Domains (2) summary
      smart00115
      Location:152400
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08325
      Location:687
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      10746338..10882295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264944.1XP_063121014.1  caspase-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACX6, A6KQJ9
      Related
      ENSRNOP00000009993.6, ENSRNOT00000009993.8

    RNA

    1. XR_005487743.1 RNA Sequence

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