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Fkbp7 FKBP prolyl isomerase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295672, updated on 4-Jan-2025

Summary

Official Symbol
Fkbp7provided by RGD
Official Full Name
FKBP prolyl isomerase 7provided by RGD
Primary source
RGD:1305293
See related
EnsemblRapid:ENSRNOG00000011758 AllianceGenome:RGD:1305293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in endoplasmic reticulum. Orthologous to human FKBP7 (FKBP prolyl isomerase 7). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 117.5), Uterus (RPKM 99.3) and 9 other tissues See more
Orthologs
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Genomic context

See Fkbp7 in Genome Data Viewer
Location:
3q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (82016647..82030913, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (61609384..61623710, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (63522480..63535835, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486118 Neighboring gene protein activator of interferon induced protein kinase EIF2AK2 Neighboring gene pejvakin Neighboring gene uncharacterized LOC134486119 Neighboring gene pleckstrin homology domain containing A3 Neighboring gene titin Neighboring gene uncharacterized LOC120101583

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in endoplasmic reticulum  

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP7
Names
FK506 binding protein 7
NP_001099955.2
XP_006234462.1
XP_017447036.1
XP_038960423.1
XP_063139346.1
XP_063139347.1
XP_063139348.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106485.4NP_001099955.2  peptidyl-prolyl cis-trans isomerase FKBP7 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HMI1
    Related
    ENSRNOP00000086609.2, ENSRNOT00000108707.2
    Conserved Domains (3) summary
    cd15899
    Location:147174
    EFh_CREC; EF-hand motif [structural motif]
    cl25354
    Location:147213
    EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
    pfam00254
    Location:42137
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    82016647..82030913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234400.5XP_006234462.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AE14, A6HMI1
    Conserved Domains (3) summary
    pfam00254
    Location:42136
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:147209
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:147208
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. XM_017591547.3XP_017447036.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X2

    UniProtKB/TrEMBL
    A6HMI1
    Conserved Domains (3) summary
    cd15899
    Location:147174
    EFh_CREC; EF-hand motif [structural motif]
    cl25354
    Location:147213
    EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
    pfam00254
    Location:42137
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  3. XM_039104495.2XP_038960423.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X6

    Conserved Domains (3) summary
    cd15899
    Location:3665
    EFh_CREC; EF-hand motif [structural motif]
    cl25354
    Location:36107
    EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
    cl19519
    Location:928
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  4. XM_063283278.1XP_063139348.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X5

  5. XM_063283277.1XP_063139347.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A5N3
  6. XM_063283276.1XP_063139346.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X1

RNA

  1. XR_010064576.1 RNA Sequence

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