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    Trpc1 transient receptor potential cation channel, subfamily C, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89821, updated on 4-Jan-2025

    Summary

    Symbol
    Trpc1provided by RGD
    Full Name
    transient receptor potential cation channel, subfamily C, member 1provided by RGD
    Primary source
    RGD:619783
    See related
    EnsemblRapid:ENSRNOG00000054902 AllianceGenome:RGD:619783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trrp1
    Summary
    Predicted to enable several functions, including ATPase binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Involved in cellular response to hypoxia and modulation of chemical synaptic transmission. Is active in postsynaptic membrane and presynaptic membrane. Biomarker of type 2 diabetes mellitus. Orthologous to human TRPC1 (transient receptor potential cation channel subfamily C member 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 76.3), Heart (RPKM 61.6) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Trpc1 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (105142931..105193842, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (96263322..96314220, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (103503982..103554905, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member 9 Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene inosine triphosphatase, pseudogene 1 Neighboring gene uncharacterized LOC120094233 Neighboring gene plastin 1 Neighboring gene uncharacterized LOC120094232

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding  
    enables ATPase binding  
    enables calcium channel activity  
    enables inositol 1,4,5 trisphosphate binding  
    enables inositol 1,4,5 trisphosphate binding  
    enables inositol 1,4,5 trisphosphate binding  
    enables monoatomic cation channel activity  
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables store-operated calcium channel activity  
    enables store-operated calcium channel activity  
    enables store-operated calcium channel activity  
    enables store-operated calcium channel activity  
    enables transmembrane transporter binding  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transmembrane transport  
    involved_in cellular response to hypoxia PubMed 
    involved_in melanin biosynthetic process  
    involved_in melanin biosynthetic process  
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in positive regulation of membrane hyperpolarization  
    involved_in positive regulation of release of sequestered calcium ion into cytosol  
    involved_in positive regulation of release of sequestered calcium ion into cytosol  
    involved_in regulation of cytosolic calcium ion concentration  
    involved_in regulation of cytosolic calcium ion concentration  
    involved_in regulation of cytosolic calcium ion concentration  
    involved_in relaxation of vascular associated smooth muscle  
    involved_in response to calcium ion  
    involved_in response to calcium ion  
    acts_upstream_of_or_within saliva secretion  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane  
    part_of cation channel complex  
    located_in costamere  
    located_in cytoplasm  
    located_in membrane  
    located_in membrane raft  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic membrane PubMed 
    is_active_in presynaptic membrane PubMed 
    part_of protein-containing complex  
    part_of receptor complex  
    part_of receptor complex  
    located_in sarcomere  

    General protein information

    Preferred Names
    short transient receptor potential channel 1
    Names
    TRP-1
    short transient receptor potential channel 1-like
    transient receptor protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413355.1 → NP_001400284.1  short transient receptor potential channel 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K7J3, Q0PG39
      Related
      ENSRNOP00000074229.3, ENSRNOT00000089833.3
    2. NM_001429254.1 → NP_001416183.1  short transient receptor potential channel 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9QX01
      UniProtKB/TrEMBL
      A6I264
    3. NM_053558.3 → NP_446010.2  short transient receptor potential channel 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q9QX01
      Related
      ENSRNOP00000072139.2, ENSRNOT00000079965.3
      Conserved Domains (2) summary
      TIGR00870
      Location:48 → 740
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:83 → 117
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      105142931..105193842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082220.2 → XP_038938148.1  short transient receptor potential channel 1 isoform X5

      UniProtKB/Swiss-Prot
      Q9QX01
      Conserved Domains (1) summary
      TIGR00870
      Location:25 → 661
      trp; transient-receptor-potential calcium channel protein
    2. XM_063266254.1 → XP_063122324.1  short transient receptor potential channel 1 isoform X2

      UniProtKB/Swiss-Prot
      Q9QX01
    3. XM_063266253.1 → XP_063122323.1  short transient receptor potential channel 1 isoform X1

      UniProtKB/TrEMBL
      Q0PG39
    4. XM_063266255.1 → XP_063122325.1  short transient receptor potential channel 1 isoform X6

    5. XM_039082218.2 → XP_038938146.1  short transient receptor potential channel 1 isoform X3

      UniProtKB/TrEMBL
      Q0PG39
      Conserved Domains (1) summary
      TIGR00870
      Location:14 → 695
      trp; transient-receptor-potential calcium channel protein
    6. XM_039082219.2 → XP_038938147.1  short transient receptor potential channel 1 isoform X4

      UniProtKB/Swiss-Prot
      Q9QX01
      Conserved Domains (1) summary
      TIGR00870
      Location:48 → 684
      trp; transient-receptor-potential calcium channel protein
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