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Psmb8 proteasome 20S subunit beta 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24968, updated on 4-Jan-2025

Summary

Symbol
Psmb8provided by RGD
Full Name
proteasome 20S subunit beta 8provided by RGD
Primary source
RGD:3426
See related
EnsemblRapid:ENSRNOG00000000456 AllianceGenome:RGD:3426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lmp7; Ring10
Summary
Predicted to enable endopeptidase activity. Predicted to be involved in fat cell differentiation; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of endopeptidase activity. Predicted to act upstream of or within antigen processing and presentation. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, beta-subunit complex and spermatoproteasome complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 1. Orthologous to human PSMB8 (proteasome 20S subunit beta 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 761.5), Spleen (RPKM 502.4) and 8 other tissues See more
Orthologs
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Genomic context

See Psmb8 in Genome Data Viewer
Location:
20p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4654068..4657049, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4652159..4655122, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3990809..3993772)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene RT1 class II, locus DOb Neighboring gene transporter 2, ATP binding cassette subfamily B member Neighboring gene transporter 1, ATP binding cassette subfamily B member Neighboring gene proteasome 20S subunit beta 9

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC124945

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity  
enables threonine-type endopeptidase activity  
Component Evidence Code Pubs
located_in cytoplasm  
is_active_in cytosol  
is_active_in nucleus  
located_in nucleus  
part_of proteasome complex  
part_of proteasome core complex  
part_of proteasome core complex  
part_of proteasome core complex  
part_of proteasome core complex PubMed 
part_of proteasome core complex, beta-subunit complex  
part_of proteasome core complex, beta-subunit complex  
part_of spermatoproteasome complex  
part_of spermatoproteasome complex  
part_of spermatoproteasome complex  

General protein information

Preferred Names
proteasome subunit beta type-8
Names
large multifunctional protease 7
low molecular mass polypeptide 7
macropain subunit C13
multicatalytic endopeptidase complex subunit C13
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
proteasome (prosome, macropain) subunit, beta type, 8
proteasome component C13
proteasome subunit beta 8
proteasome subunit beta type-8-like
proteasome subunit beta-5i
NP_542945.2
XP_063135031.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080767.2NP_542945.2  proteasome subunit beta type-8

    See identical proteins and their annotated locations for NP_542945.2

    Status: VALIDATED

    Source sequence(s)
    BX883043
    UniProtKB/Swiss-Prot
    P28064, Q6MGA4
    UniProtKB/TrEMBL
    A0A023IKD2, A0A023IM45, A0A023IMI6
    Related
    ENSRNOP00000000528.5, ENSRNOT00000000528.8
    Conserved Domains (2) summary
    PTZ00488
    Location:40271
    PTZ00488; Proteasome subunit beta type-5; Provisional
    cd03761
    Location:73260
    proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    4654068..4657049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278961.1XP_063135031.1  proteasome subunit beta type-8 isoform X1

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